Document Detail


Maternal obesity at conception programs obesity in the offspring.
MedLine Citation:
PMID:  18032473     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Risk of obesity in adult life is subject to programming during gestation. To examine whether in utero exposure to maternal obesity increases the risk of obesity in offspring, we developed an overfeeding-based model of maternal obesity in rats utilizing intragastric feeding of diets via total enteral nutrition. Feeding liquid diets to adult female rats at 220 kcal/kg(3/4) per day (15% excess calories/day) compared with 187 kcal/kg(3/4) per day for 3 wk caused substantial increase in body weight gain, adiposity, serum insulin, leptin, and insulin resistance. Lean or obese female rats were mated with ad libitum AIN-93G-fed male rats. Exposure to obesity was ensured to be limited only to the maternal in utero environment by cross-fostering pups to lean dams having ad libitum access to AIN-93G diets throughout lactation. Numbers of pups, birth weight, and size were not affected by maternal obesity. Male offspring from each group were weaned at postnatal day (PND)21 to either AIN-93G diets or high-fat diets (45% fat calories). Body weights of offspring from obese dams did not differ from offspring of lean dams when fed AIN-93G diets through PND130. However, offspring from obese dams gained remarkably greater (P < 0.005) body weight and higher % body fat when fed a high-fat diet. Body composition was assessed by NMR, X-ray computerized tomography, and weights of adipose tissues. Adipose histomorphometry, insulin sensitivity, and food intake were also assessed in the offspring. Our data suggest that maternal obesity at conception leads to fetal programming of offspring, which could result in obesity in later life.
Authors:
Kartik Shankar; Amanda Harrell; Xiaoli Liu; Janet M Gilchrist; Martin J J Ronis; Thomas M Badger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-11-21
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  294     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-31     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R528-38     Citation Subset:  IM    
Affiliation:
Arkansas Children's Nutrition Center, 1212 Marshall Street, Little Rock, AR 72202, USA. ShankarKartik@uams.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Animals
Animals, Newborn
Body Composition*
Body Weight / physiology
Dietary Fats / pharmacology*
Energy Intake / physiology
Energy Metabolism / physiology
Female
Male
Obesity / metabolism*
Pregnancy
Pregnancy Complications / metabolism*
Prenatal Exposure Delayed Effects / metabolism*
Rats
Chemical
Reg. No./Substance:
0/Dietary Fats

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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