Document Detail

Maternal nutritional programming of fetal adipose tissue development: differential effects on messenger ribonucleic acid abundance for uncoupling proteins and peroxisome proliferator-activated and prolactin receptors.
MedLine Citation:
PMID:  15961559     Owner:  NLM     Status:  MEDLINE    
Maternal nutrient restriction at specific stages of gestation has differential effects on fetal development such that the offspring are programmed to be at increased risk of a range of adult diseases, including obesity. We investigated the effect of maternal nutritional manipulation through gestation on fetal adipose tissue deposition in conjunction with mRNA abundance for uncoupling protein (UCP)1 and 2, peroxisome proliferator-activated receptors (PPAR)alpha and gamma, together with long and short forms of the prolactin receptor (PRLR). Singleton-bearing ewes were either nutrient restricted (3.2-3.8 MJ day(-1) metabolizable energy) or fed to appetite (8.7-9.9 MJ day(-1)) over the period of maximal placental growth, i.e. between 28 and 80 d gestation. After 80 d gestation, ewes were either fed to calculated requirements, (6.7-7.5 MJ day(-1)), or to appetite (8.0-10.9 MJ day(-1)). At term, offspring of nutrient-restricted ewes possessed more adipose tissue, an adaptation that was greatest in those born to mothers that fed to requirements in late gestation. This was accompanied by an increased mRNA abundance for UCP2 and PPARalpha, an adaptation not seen in mothers re-fed to appetite. Maternal nutrition had no effect on mRNA abundance for UCP1, PPARgamma, or PRLR. Irrespective of maternal nutrition, mRNA abundance for UCP1 was positively correlated with PPARgamma and the long and short forms of PRLR, indicating that these factors may act together to ensure that UCP1 abundance is maximized in the newborn. In conclusion, we have shown, for the first time, differential effects of maternal nutrition on key regulatory components of fetal fat metabolism.
J Bispham; D S Gardner; M G Gnanalingham; T Stephenson; M E Symonds; H Budge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-06-16
Journal Detail:
Title:  Endocrinology     Volume:  146     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-17     Completed Date:  2005-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3943-9     Citation Subset:  AIM; IM    
Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, United Kingdom.
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MeSH Terms
Adipose Tissue / embryology,  physiology*
Carrier Proteins / genetics*
Fetal Nutrition Disorders / physiopathology*
Fetus / physiopathology
Ion Channels
Membrane Proteins / genetics*
Membrane Transport Proteins / genetics
Mitochondrial Proteins / genetics
PPAR alpha / genetics*
PPAR gamma / genetics*
RNA, Messenger / metabolism
Receptors, Prolactin / genetics*
Reg. No./Substance:
0/Carrier Proteins; 0/Ion Channels; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/Mitochondrial Proteins; 0/PPAR alpha; 0/PPAR gamma; 0/RNA, Messenger; 0/Receptors, Prolactin; 0/mitochondrial uncoupling protein; 0/mitochondrial uncoupling protein 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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