Document Detail

Maternal nutrition affects the ability of treatment with IGF-I and IGF-II to increase growth of the placenta and fetus, in guinea pigs.
MedLine Citation:
PMID:  11914027     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate how administration of IGF-I and IGF-II, during early to mid pregnancy, affects maternal growth and body composition as well as fetal and placental growth, in ad libitum fed, and in moderately, chronically food restricted guinea pigs. From day 20 of gestation, mothers (3-4 months old) were infused with IGF-I, IGF-II (565 microg/day) or vehicle for 17 days and then killed on day 40 of gestation. Maternal organ weights, fetal and placental weights were assessed. Treatment with IGFs did not alter body weight gain and had small effects on body composition in the mothers. Both IGF-I and IGF-II increased fetal and placental weights in ad libitum fed dams and IGF-I increased placental weight in food restricted dams. In conclusion, treatment with IGF-I during the first half of pregnancy stimulates placental growth in both ad libitum fed and food restricted guinea pigs without affecting maternal growth while fetal growth is stimulated by IGF treatment only in ad libitum fed animals.
A Sohlström; P Fernberg; J A Owens; P C Owens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  11     ISSN:  1096-6374     ISO Abbreviation:  Growth Horm. IGF Res.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-06-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  392-8     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Elsevier Science Ltd.
Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden.
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MeSH Terms
Body Composition / drug effects
Eating / drug effects
Embryonic and Fetal Development / drug effects*
Food Deprivation
Gestational Age
Guinea Pigs
Insulin-Like Growth Factor I / pharmacology*,  physiology
Insulin-Like Growth Factor II / pharmacology*,  physiology
Nutritional Physiological Phenomena / physiology*
Organ Size / drug effects
Placenta / drug effects*,  growth & development
Weight Gain / drug effects
Reg. No./Substance:
67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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