Document Detail

Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study.
MedLine Citation:
PMID:  23253182     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy.
METHODS: Within the LINA cohort study (Lifestyle and environmental factors and their Influence on Newborns Allergy risk), 25(OH)D was measured in blood samples of 378 mother-child pairs during pregnancy and at birth. Information about children's atopic manifestations during the first 2 years of life was obtained from questionnaires filled out by the parents during pregnancy and annually thereafter. Cord blood regulatory T cells (Treg) were detected by methylation-specific PCR using a Treg-specific demethylated region in the FOXP3 gene.
RESULTS: The median maternal 25(OH)D(3) level was 22.19 ng/ml (IQR 14.40-31.19 ng/ml); the median cord blood 25(OH)D(3) 10.95 ng/ml (6.99-17.39 ng/ml). A high correlation was seen between maternal and cord blood 25(OH)D(3) levels, both showing a seasonal distribution. Maternal and cord blood 25(OH)D(3) was positively associated with children's risk for food allergy within the first 2 years. Further, higher maternal 25(OH)D(3) resulted in a higher risk for sensitization against food allergens at the age of two. Cord blood 25(OH)D(3) levels were negatively correlated with regulatory T cell numbers.
CONCLUSION: Our study demonstrates that high vitamin D levels in pregnancy and at birth may contribute to a higher risk for food allergy and therefore argues against vitamin D supplement to protect against allergy.
K Weisse; S Winkler; F Hirche; G Herberth; D Hinz; M Bauer; S Röder; U Rolle-Kampczyk; M von Bergen; S Olek; U Sack; T Richter; U Diez; M Borte; G I Stangl; I Lehmann
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-18
Journal Detail:
Title:  Allergy     Volume:  68     ISSN:  1398-9995     ISO Abbreviation:  Allergy     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-06-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  220-8     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd.
Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig.
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MeSH Terms
Cohort Studies
Dermatitis, Atopic / epidemiology,  etiology*,  physiopathology
Dietary Supplements / adverse effects*
Fetal Blood
Germany / epidemiology
Hypersensitivity / epidemiology,  etiology*
Immunoglobulin E / immunology,  metabolism
Infant, Newborn
Pregnancy / blood*
Risk Assessment
Statistics, Nonparametric
T-Lymphocytes, Regulatory / immunology,  metabolism
Vitamin D / blood*
Reg. No./Substance:
1406-16-2/Vitamin D; 37341-29-0/Immunoglobulin E
Comment In:
Expert Rev Clin Immunol. 2013 Sep;9(9):817-20   [PMID:  24070045 ]

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