| Maternal and newborn vitamin D status and its impact on food allergy development in the German LINA cohort study. | |
| | |
MedLine Citation:
|
PMID: 23253182 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Vitamin D levels are known to be associated with atopic disease development; however, existing data are controversial. The aim of this study was to investigate whether corresponding maternal and cord blood vitamin D levels are associated with atopic outcomes in early infancy. METHODS: Within the LINA cohort study (Lifestyle and environmental factors and their Influence on Newborns Allergy risk), 25(OH)D was measured in blood samples of 378 mother-child pairs during pregnancy and at birth. Information about children's atopic manifestations during the first 2 years of life was obtained from questionnaires filled out by the parents during pregnancy and annually thereafter. Cord blood regulatory T cells (Treg) were detected by methylation-specific PCR using a Treg-specific demethylated region in the FOXP3 gene. RESULTS: The median maternal 25(OH)D(3) level was 22.19 ng/ml (IQR 14.40-31.19 ng/ml); the median cord blood 25(OH)D(3) 10.95 ng/ml (6.99-17.39 ng/ml). A high correlation was seen between maternal and cord blood 25(OH)D(3) levels, both showing a seasonal distribution. Maternal and cord blood 25(OH)D(3) was positively associated with children's risk for food allergy within the first 2 years. Further, higher maternal 25(OH)D(3) resulted in a higher risk for sensitization against food allergens at the age of two. Cord blood 25(OH)D(3) levels were negatively correlated with regulatory T cell numbers. CONCLUSION: Our study demonstrates that high vitamin D levels in pregnancy and at birth may contribute to a higher risk for food allergy and therefore argues against vitamin D supplement to protect against allergy. |
| | |
Authors:
|
K Weisse; S Winkler; F Hirche; G Herberth; D Hinz; M Bauer; S Röder; U Rolle-Kampczyk; M von Bergen; S Olek; U Sack; T Richter; U Diez; M Borte; G I Stangl; I Lehmann |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-18 |
Journal Detail:
|
Title: Allergy Volume: - ISSN: 1398-9995 ISO Abbreviation: Allergy Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7804028 Medline TA: Allergy Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
|
Department of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, Leipzig. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Affect is Greater than, not Equal to, Condition: Condition and Person Effects in Affective Priming P...
Next Document: Spending on vegetable and fruit consumption could reduce all-cause mortality among older adults.