| Maternal and neonatal seroprevalence of Hepatitis B surface antigen (HBsAg) in Tripoli, Libya. | |
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MedLine Citation:
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PMID: 20351458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Pregnant women with Hepatitis B virus HBV represent a major reservoir of the virus in the community. Data regarding the prevalence of HBV in pregnant women and maternal transmission of the virus in Libya are lacking. METHODOLOGY: Hepatitis blood samples from 1,500 pregnant women and 1,500 cord blood samples of their neonates delivered at Tripoli Medical Center, Tripoli, were tested for HBsAg by ELISA technique. HBsAg-positive samples were also tested for HBeAg. RESULTS: HBsAg was detected in 1.5% (23/1,500) pregnant women and in 0.9% (14/1,500) neonates. Although HBsAg was detected at higher rate in pregnant women aged > 25 years [1.8% (22/1,235)] than in pregnant women aged < 25 years [0.4% (1/265)], the difference was not statistically significant (P > 0.05). All HBsAg-positive neonates were born to HBsAg-positive mothers with a rate of maternal transmission at 60.9% (14/23). HBeAg was detected in 21.7% (5/23) and in 7.1% (1/14) of HBsAg-positive pregnant women and neonates, respectively. CONCLUSIONS: Because of the high risk of developing chronic HBV infection at birth among infants born to HBsAg-positive mothers, administration of HBIG in combination with hepatitis B vaccine as post-exposure prophylaxis for such infants is of paramount importance. In addition, universal HBsAg screening of all pregnant women will greatly assist in reducing the maternal transmission of HBV in the country. |
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Authors:
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Hamida El-Magrahe; Abdul Rahaman Furarah; Kheiria El-Figih; Sued El-Urshfany; Khalifa Sifaw Ghenghesh |
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Publication Detail:
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Type: Journal Article Date: 2010-03-29 |
Journal Detail:
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Title: Journal of infection in developing countries Volume: 4 ISSN: 1972-2680 ISO Abbreviation: J Infect Dev Ctries Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-30 Completed Date: 2010-06-16 Revised Date: 2010-09-14 |
Medline Journal Info:
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Nlm Unique ID: 101305410 Medline TA: J Infect Dev Ctries Country: Italy |
Other Details:
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Languages: eng Pagination: 168-70 Citation Subset: IM |
Affiliation:
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Faculty of Sciences, Al-Fateh University, Tripoli, Libya. hamidaelmagrahe_mojab@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Female Hepatitis B Surface Antigens / immunology* Hepatitis B virus / immunology* Hepatitis B, Chronic / epidemiology*, etiology, prevention & control Humans Infant, Newborn Infectious Disease Transmission, Vertical Libya / epidemiology Post-Exposure Prophylaxis Pregnancy Pregnancy Complications, Infectious / epidemiology*, etiology, prevention & control Prevalence Seroepidemiologic Studies |
| Chemical | |
Reg. No./Substance:
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0/Hepatitis B Surface Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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