Document Detail

Maternal and neonatal risk factors for mental retardation: defining the 'at-risk' child.
MedLine Citation:
PMID:  9483389     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine how mental retardation at age seven is related to certain maternal, perinatal, and neonatal characteristics. METHOD: A sample of 35,704 children followed from the prenatal period to age 7 years in the Collaborative Perinatal Project provided data on nine maternal and pregnancy characteristics and 12 neonatal factors. RESULTS: Low socioeconomic status of the family (SES) accounted for 44-50% of mental retardation and a low level of maternal education accounted for 20%. Other prenatal factors with significantly elevated relative risks, (P < 0.05) were maternal IQ score less than 70, weight gain in pregnancy less than 10 pounds and multiple birth. Maternal anemia in pregnancy accounted for 14% of mental retardation in blacks, and, urinary tract infections accounted for 6% of mental retardation in whites. Significant elevations in relative risk were found for major genetic and post-infection syndromes, CNS malformations, cerebral palsy, seizures, abnormal movements or tone, and low birth weight. Relative risk was also significantly increased with low 1 minute APGAR, primary apnea, and head circumference and length more than 2 SD below average but only in the low SES black subgroup. CONCLUSION: Early developmental events can be ranked on the basis of the strength of their association with mental retardation and such rankings can be used as a guide for defining risk status in early infancy.
B W Camp; S H Broman; P L Nichols; M Leff
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Early human development     Volume:  50     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-04-01     Completed Date:  1998-04-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  159-73     Citation Subset:  IM    
Department of Pediatrics, University of Colorado, School of Medicine, Denver, USA.
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MeSH Terms
Apgar Score
Apnea / complications
Central Nervous System / abnormalities
Cohort Studies
Ethnic Groups
Follow-Up Studies
Infant, Newborn
Mental Retardation / epidemiology*,  etiology
Mother-Child Relations
Pregnancy Complications
Risk Factors
Socioeconomic Factors
Wechsler Scales

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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