| Maternal, neonatal, and placental features associated with diffuse chorioamniotic hemosiderosis, with special reference to neonatal morbidity and mortality. | |
| | |
MedLine Citation:
|
PMID: 15060230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Our purpose was to examine the significance of diffuse chorioamniotic hemosiderosis (DCH) on neonatal morbidity and mortality. METHODS: Using data from a retrospective case-control study, we analyzed 46 singleton placentas with DCH from infants who were delivered and/or admitted to the neonatal intensive care unit of Kanagawa Children's Medical Center during 1987-2001 and 92 control placentas without DCH from infants of comparable gestational age, birth weight, and duration. RESULTS: Mean and standard deviation of gestational age and infants' birth weight at delivery from the DCH group were 27 +/- 3 weeks and 939 +/- 342 g, respectively. Macroscopically, the placentas with DCH were more likely to show old peripheral blood clots (46% in the DCH group vs 8% in control group), subchorionic hematoma (20% vs 1%), and circumvallation (13% vs 1%). Histologically, amniotic necrosis was significantly more frequent in the DCH group (63% vs 24%). Of the obstetric factors, incidence of recurrent episodes of vaginal bleeding (70% vs 11%), oligohydramnios (59% vs 8%), and chronic abruption-oligohydramnios sequence (57% vs 5%) were significantly higher in the DCH group. Of the neonatal factors, persistent pulmonary hypertension of the newborn (29% vs 8%) and dry lung and/or pulmonary hypoplasia (20% vs 4%) were more common. However, respiratory distress syndrome was rare (15% vs 45%) in the DCH group. Neonatal death including stillbirth was increased in the DCH group but was not significant (24% vs 15%). Of infants who survived beyond day 28, chronic lung disease (CLD) was more frequent in the DCH group (51% vs 22%). The association of DCH, especially accompanied by amniotic necrosis, with CLD was still evident using likelihood ratio test. CONCLUSION: DCH is closely associated with preterm delivery, pulmonary hypertension of the newborn, and dry lung syndrome and is a significant risk factor for CLD. |
| | |
Authors:
|
Makiko Ohyama; Yasufumi Itani; Michiko Yamanaka; Akiko Goto; Keisuke Kato; Rieko Ijiri; Yukichi Tanaka |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Pediatrics Volume: 113 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2004 Apr |
Date Detail:
|
Created Date: 2004-04-02 Completed Date: 2004-05-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
|
Languages: eng Pagination: 800-5 Citation Subset: AIM; IM |
Affiliation:
|
Division of Neonatology, Kanagawa Children's Medical Center, Yokohama City, Japan. neoohyama@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abruptio Placentae
/
etiology Amnion Case-Control Studies Chorion / chemistry Female Hemosiderosis / complications*, pathology* Humans Infant Mortality Infant, Newborn Infant, Premature* Iron / analysis Likelihood Functions Lung / abnormalities Lung Diseases Oligohydramnios / etiology Persistent Fetal Circulation Syndrome Placenta / pathology* Pregnancy Pregnancy Outcome Respiratory Distress Syndrome, Newborn Retrospective Studies Uterine Hemorrhage / etiology |
| Chemical | |
Reg. No./Substance:
|
7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Educational and social competencies at 8 years in children with threshold retinopathy of prematurity...
Next Document: Risk factors for emesis after therapeutic use of activated charcoal in acutely poisoned children.