Document Detail


Maternal and neonatal outcomes of spontaneously conceived pregnancies in mothers over 45 years: a review of the literature.
MedLine Citation:
PMID:  22262490     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: There is little published data on pregnancy outcomes in women who had conceived spontaneously after age 45 years. The aim of this review is to provide accurate information on the risks and probable outcomes of spontaneously conceived pregnancies in women over the age of 45 years, which will enable clinicians to counsel such women appropriately, carry out adequate risk assessment, and ensure better care for pregnancies in this population. DESIGN: A literature search was performed using EmBase and PubMed for English language articles published between 1970 and 2011, with extractable data on mothers aged ≥45 at the time of delivery and with ≥95% spontaneous conception in the study population. RESULTS: Six such studies with a total pooled number of 505 women were identified. Overall, there is increased maternal morbidity and rates of caesarean section, as well as higher incidence of premature births and admission to special care baby unit. Contrary to popular belief, career is not always an important factor in delaying childbearing, especially in developing countries. Other factors may include cultural acceptance of large families and lack of contraception, although more research may be carried out in order to explain these hypotheses. CONCLUSION: Pooled retrospective data suggest that women who conceived spontaneously after the age of 45 years have increased maternal morbidity and rates of caesarean section, as well as higher incidence of premature births and admission to special care baby unit.
Authors:
Li-An Wong-Taylor; Alexandra Lawrence; Sophie Cowen; Hetty Jones; Maud Nauta; Zeudi Ramsay-Marcelle; Wai Yoong
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-20
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
UCL Medical School, Gower St, London, WC1 6BT, UK.
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