| Maternal and neonatal outcomes of dose-dense chemotherapy for breast cancer in pregnancy. | |
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MedLine Citation:
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PMID: 23168749 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: : To estimate the effect of dose-dense chemotherapy during pregnancy on maternal and neonatal outcomes. METHODS: : This is a retrospective cohort study in which women were identified from the international Cancer and Pregnancy Registry at Cooper Medical School at Rowan University in Camden, New Jersey. A chart analysis was completed and Fisher's exact test and independent t test were used in comparing patient outcomes. RESULTS: : Ten women received dose-dense chemotherapy, received every 2 weeks, and 99 women received conventional chemotherapy, received with at least 3-week intervals, for breast cancer during pregnancy. Birth weight, gestational age at delivery, rate of growth restriction, congenital anomalies, and incidence of maternal and neonatal neutropenia were not statistically different between the two groups. CONCLUSION: : In the small cohort of women in our registry, dose-dense chemotherapy does not appear to increase the risk of fetal or maternal complications. LEVEL OF EVIDENCE: : II. |
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Authors:
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Elyce Cardonick; Dzhamala Gilmandyar; Robert A Somer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 120 ISSN: 1873-233X ISO Abbreviation: Obstet Gynecol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1267-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, and the Department of Medicine, Division of Hematology and Medical Oncology, Cooper University Hospital, Camden, New Jersey; and the Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Medical Center, Rochester, New York. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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