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Maternal and neonatal outcomes of dose-dense chemotherapy for breast cancer in pregnancy.
MedLine Citation:
PMID:  23168749     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: : To estimate the effect of dose-dense chemotherapy during pregnancy on maternal and neonatal outcomes.
METHODS: : This is a retrospective cohort study in which women were identified from the international Cancer and Pregnancy Registry at Cooper Medical School at Rowan University in Camden, New Jersey. A chart analysis was completed and Fisher's exact test and independent t test were used in comparing patient outcomes.
RESULTS: : Ten women received dose-dense chemotherapy, received every 2 weeks, and 99 women received conventional chemotherapy, received with at least 3-week intervals, for breast cancer during pregnancy. Birth weight, gestational age at delivery, rate of growth restriction, congenital anomalies, and incidence of maternal and neonatal neutropenia were not statistically different between the two groups.
CONCLUSION: : In the small cohort of women in our registry, dose-dense chemotherapy does not appear to increase the risk of fetal or maternal complications.
LEVEL OF EVIDENCE: : II.
Authors:
Elyce Cardonick; Dzhamala Gilmandyar; Robert A Somer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  120     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1267-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, and the Department of Medicine, Division of Hematology and Medical Oncology, Cooper University Hospital, Camden, New Jersey; and the Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Medical Center, Rochester, New York.
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