Document Detail

Maternal and neonatal morbidities associated with obstructive sleep apnea complicating pregnancy.
MedLine Citation:
PMID:  20005507     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of the study was to estimate the maternal and neonatal morbidities associated with obstructive sleep apnea (OSA) in pregnancy. STUDY DESIGN: Women delivering between 2000-2008 with confirmed OSA in an academic center were included. Normal-weight and obese controls were randomly selected at a 2:1 ratio. Maternal and neonatal morbidities were compared between the groups. Multivariate analyses were performed to evaluate maternal morbidity and preterm birth (PTB). RESULTS: The analysis included 57 pregnancies complicated by OSA. Compared with normal-weight (n = 114) controls, OSA patients had more preeclampsia (PET) (19.3% vs 7.0%; P = .02) and PTB (29.8% vs 12.3%; P = .007). Controlling for comorbid conditions, OSA was associated with an increased risk of PTB (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.02-6.6), mostly secondary to PET (63%). Cesarean delivery (OR, 8.1; 95% CI, 2.9-22.1) and OSA were associated with maternal morbidity (OR, 4.6; 95% CI, 1.5-13.7). CONCLUSION: Pregnancies complicated by OSA are at increased risk for preeclampsia, medical complications, and indicated PTB.
Judette M Louis; Dennis Auckley; Robert J Sokol; Brian M Mercer
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Publication Detail:
Type:  Journal Article     Date:  2009-12-14
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  202     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-08     Completed Date:  2010-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261.e1-5     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, OH, USA.
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MeSH Terms
Case-Control Studies
Cesarean Section / statistics & numerical data
Cohort Studies
Diabetes Mellitus / epidemiology
Multivariate Analysis
Obesity / epidemiology
Pre-Eclampsia / epidemiology*
Pregnancy Complications / epidemiology*
Premature Birth / epidemiology*
Retrospective Studies
Sleep Apnea, Obstructive / epidemiology*

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