Document Detail


Maternal and neonatal interleukin-1 receptor antagonist genotype and pregnancy outcome in a population with a high rate of pre-term birth.
MedLine Citation:
PMID:  18754838     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PROBLEM: We evaluated associations between a length polymorphism in intron 2 of the gene coding for IL-1ra (gene symbol IL1RN) and pregnancy outcome in a population with a high rate of preterm birth. METHOD OF STUDY: Subjects were pregnant women in Maceio, Brazil and their newborns. DNA was tested for IL1RN genotypes and alleles by gene amplification using primer pairs that spanned the polymorphic region. Every subject completed a detailed questionnaire. RESULTS: The frequency of allele 2 (IL1RN*2) carriage was elevated in mothers with a spontaneous preterm birth (SPTB) in the current pregnancy (P = 0.02) and also with a prior preterm delivery (P = .01). Both SPTB with intact membranes (P = 0.01) and SPTB preceded by pre-term premature rupture of membranes (P = .03) were associated with ILlRN*2 carriage. A previous fetal demise was more than twice as prevalent in mothers positive for two copies of IL1RN*2. CONCLUSION: Maternal carriage of ILlRN*2 increases susceptibility to inflammation-triggered spontaneous pre-term birth.
Authors:
José Humberto Belmino Chaves; Arthur Babayan; Cledna de Melo Bezerra; Iara M Linhares; Steven S Witkin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  60     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-12-12     Completed Date:  2009-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
Affiliation:
Universidade Estadual de Ciências da Saúde de Alagoas, Maceio, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alleles
Brazil / epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Infant, Newborn
Interleukin 1 Receptor Antagonist Protein / genetics*
Polymorphism, Genetic
Pregnancy
Pregnancy Outcome / epidemiology,  genetics*
Premature Birth / epidemiology,  genetics*
Young Adult
Chemical
Reg. No./Substance:
0/Interleukin 1 Receptor Antagonist Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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