Document Detail

Maternal and neonatal factors and mortality in children with Down syndrome born in 1973-1980 and 1995-1998.
MedLine Citation:
PMID:  14989449     Owner:  NLM     Status:  MEDLINE    
AIMS: To investigate maternal and neonatal factors in Down syndrome (DS) at birth, the impact of a congenital heart defect (CHD) on these factors and changes over time. METHODS: Medical data of children with DS born in northern Sweden in the periods 1973-1980 (n = 219) and 1995-1998 (n = 88) obtained from the Swedish Medical Birth Register were compared. A comparison with the general population on a group level was also made. RESULTS: The main finding was a reduction in infant mortality in DS, from 14.2% to 2.3% in 1995-1998 (p < 0.001), but this was still significantly higher than in the general population. The rate of Caesarean sections increased over time (from 14.5% to 27.3%, p < 0.05) even after adjustment for increased maternal age. No change over time was detected in the following rates: premature birth (gestational age < or = 36) (25%); asphyxia (5-min Apgar score < or = 6) (8%); low birthweight (< 2500 g) (14%); or small for gestational age (SGA) (14%); all rates were significantly higher than those of the general population. A CHD did not seem to influence the rates of these factors in a logistic regression model. CONCLUSION: Infant mortality decreased substantially over time in the DS group, whereas there was no reduction in the rate of asphyxia, SGA, low birthweight or prematurity. The presence of a CHD did not influence any of the neonatal factors studied.
C Frid; P Drott; P Otterblad Olausson; C Sundelin; G Annerén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  93     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-03-01     Completed Date:  2004-05-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
Unit of Paediatrics, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Asphyxia / complications
Cesarean Section
Down Syndrome / etiology,  mortality*
Gestational Age
Heart Defects, Congenital / complications
Infant Mortality*
Infant, Newborn
Maternal Age*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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