Document Detail

Maternal and neonatal factors impacting response to methadone therapy in infants treated for neonatal abstinence syndrome.
MedLine Citation:
PMID:  20508596     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify maternal and neonatal factors that impact response to methadone therapy for neonatal abstinence syndrome.
STUDY DESIGN: This is a retrospective review of 128 infants that received pharmacotherapy for opiate withdrawal to identify factors associated with favorable response to methadone therapy. Maternal and neonatal data were analyzed with univariate statistics and multivariate logistic regression.
RESULT: Maternal methadone maintenance dose during pregnancy correlated with length of stay (P=0.009). There was an inverse correlation between the amount of mother's breast milk ingested and length of stay (β=-0.03, P=0.02). Methadone was initiated later, tapered more rapidly and was more successful as monotherapy in preterm infants. Five percent of infants were admitted to hospital again for rebound withdrawal following reduction of breast milk intake.
CONCLUSION: Severity of neonatal abstinence syndrome may be mitigated by titrating methadone to the lowest effective dose during pregnancy and by encouraging breast milk feeds, which should be weaned gradually.
B Isemann; J Meinzen-Derr; H Akinbi
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Publication Detail:
Type:  Journal Article     Date:  2010-05-27
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  31     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-29     Completed Date:  2011-04-14     Revised Date:  2012-03-06    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Department of Pharmacy, The University Hospital, Cincinnati, OH 45219, USA.
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MeSH Terms
Breast Feeding
Dose-Response Relationship, Drug
Infant, Newborn
Infant, Premature
Length of Stay
Logistic Models
Methadone / administration & dosage*
Narcotics / administration & dosage*
Neonatal Abstinence Syndrome / drug therapy*
Opioid-Related Disorders / drug therapy*
Patient Readmission
Pregnancy Complications / drug therapy*
Retrospective Studies
Substance Withdrawal Syndrome / drug therapy*
Treatment Outcome
Reg. No./Substance:
0/Narcotics; 76-99-3/Methadone
Comment In:
J Perinatol. 2012 Feb;32(2):157-8; author reply 158   [PMID:  22289709 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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