| Maternal and neonatal effects of bolus administration of ephedrine and phenylephrine during spinal anaesthesia for caesarean delivery: a randomised study. | |
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MedLine Citation:
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PMID: 19665364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Maternal haemodynamic changes and neonatal well-being following bolus administration of ephedrine and phenylephrine were compared in 60 term parturients undergoing elective caesarean delivery under spinal anaesthesia. METHODS: In a randomised double-blind study, women received boluses of either ephedrine 6 mg (group E; n=30) or phenylephrine 100 microg (group P; n=30) whenever maternal systolic pressure was 80% of baseline. RESULTS: Changes in systolic pressure were comparable in the two groups. There were no differences in the incidence of bradycardia (group E: 0% vs. group P: 16.7%; P>0.05), nausea (group E: 13% vs. group: P 0; P>0.05) and vomiting (group E: 3.3% vs. group P: 0; P>0.05). Umbilical artery (UA) pH (group E: 7.29 +/- 0.04 vs. group P: 7.32 +/- 0.04; P=0.01) and venous pH (group E: 7.34 +/- 0.04 vs. group P: 7.38 +/- 0.05; P=0.002) were significantly greater in group P than in group E. UA base excess was significantly less in group E (-2.83 +/- 0.94 mEq/L) than in group P (-1.61 +/- 1.04 mEq/L; P<0.001). Apgar scores at 1, 5 and 10min and neurobehavioural scores at 2-4 h, 24 h and 48 h were similar in the two groups (P>0.05). CONCLUSIONS: Phenylephrine 100 mug and ephedrine 6 mg had similar efficacy in the treatment of maternal hypotension during spinal anaesthesia for elective caesarean delivery. Neonates in group P had significantly higher umbilical arterial pH and base excess values than those in group E, which is consistent with other studies. |
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Authors:
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S Prakash; V Pramanik; H Chellani; S Salhan; A R Gogia |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2009-08-07 |
Journal Detail:
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Title: International journal of obstetric anesthesia Volume: 19 ISSN: 1532-3374 ISO Abbreviation: Int J Obstet Anesth Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-19 Completed Date: 2010-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200430 Medline TA: Int J Obstet Anesth Country: Netherlands |
Other Details:
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Languages: eng Pagination: 24-30 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anaesthesia and Intensive Care, Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India. drsunilprakash@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium Adult Anesthesia, Obstetrical* / adverse effects Anesthesia, Spinal* / adverse effects Anti-Ulcer Agents / therapeutic use Antiemetics / therapeutic use Apgar Score Cesarean Section* Double-Blind Method Ephedrine / administration & dosage, therapeutic use* Female Hemodynamics / drug effects Humans Hypotension / drug therapy*, etiology Infant, Newborn Metoclopramide / therapeutic use Pain Measurement Phenylephrine / administration & dosage, therapeutic use* Postoperative Nausea and Vomiting / prevention & control Pregnancy Ranitidine / therapeutic use Sample Size Vasoconstrictor Agents / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Ulcer Agents; 0/Antiemetics; 0/Vasoconstrictor Agents; 299-42-3/Ephedrine; 364-62-5/Metoclopramide; 59-42-7/Phenylephrine; 66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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