Document Detail

Maternal and neonatal characteristics associated with neonatal neutropenia in hypertensive pregnancies.
MedLine Citation:
PMID:  19670129     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to identify maternal and neonatal characteristics affecting marked neonatal neutropenia in pregnancies complicated by hypertension. A single institution retrospective chart review over 2 years of singleton and multifetal pregnancies with hypertensive disorders meeting American College of Obstetricians and Gynecologists criteria was performed. Neutropenia and sepsis occurring within the first 16 days of life (DOL) were studied. Neutropenia was defined as an absolute neutrophil count of <1500/microL and sepsis as any positive blood, cerebrospinal fluid, or urine culture. The study group contained neonates with neutropenia. From all other hypertensive pregnancies, a presumed nonneutropenic control group was randomly generated with a 4:1 ratio; these neonates may or may not have had a complete blood count (CBC) performed because they were clinically stable. Multiple gestations were separately analyzed and compared with hypertensive multifetal neonates with confirmed CBCs showing no neutropenia. Chi-square, Mann-Whitney U, and regression analyses were performed. Five hundred forty-three hypertensive pregnancies representing 633 births, 173 (27.3%) of which were from multiple gestations, were studied. There were 32 (5.9%) cases of neutropenia, with 22 (68.8%) from multiple gestations. Of premature multiple gestations, 45.2% born between 24 and 34 weeks' gestation developed neutropenia. The median time to diagnosis of neutropenia was 1.2 hours with 80.6% detected on the first DOL. Resolution of neutropenia occurred within 7 days in 84.4% of surviving neonates. Univariate analysis showed significant associations of neutropenia with gestational age at delivery, multiple gestations, birth weight, severe preeclampsia, and development of neonatal sepsis. When multiple gestations were analyzed, linear regression showed only sepsis to be significantly associated with neutropenia (p = 0.027). Hypertensive disorders of pregnancy and premature delivery are common in multiple gestations and are associated with neutropenia (12.7% versus 2.2% neutropenia in singletons (p < 0.001). Furthermore, multiple gestations with neutropenia had a higher incidence of sepsis than singletons with neutropenia.
Geeta Sharma; Mirjana Nesin; Michael Feuerstein; James B Bussel
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Publication Detail:
Type:  Journal Article     Date:  2009-05-20
Journal Detail:
Title:  American journal of perinatology     Volume:  26     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-16     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  683-9     Citation Subset:  IM    
Copyright Information:
Thieme Medical Publishers.
Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, New York, USA.
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MeSH Terms
Blood Pressure Determination
Case-Control Studies
Chi-Square Distribution
Follow-Up Studies
Gestational Age
Hypertension, Pregnancy-Induced / diagnosis*,  epidemiology
Infant, Newborn
Infant, Newborn, Diseases / diagnosis*,  epidemiology
Neutropenia / diagnosis*,  epidemiology
Pre-Eclampsia / diagnosis,  epidemiology
Pregnancy, Multiple
Premature Birth
Reference Values
Retrospective Studies
Risk Assessment
Sepsis / diagnosis*,  epidemiology
Severity of Illness Index
Statistics, Nonparametric
Survival Analysis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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