Document Detail

Maternal myasthenia gravis complicated by fetal arthrogryposis multiplex congenita.
MedLine Citation:
PMID:  21112761     Owner:  NLM     Status:  In-Process    
We report the management of a 24-year-old primigravid woman who was diagnosed with myasthenia gravis at 20weeks of gestation. Maternal symptoms improved with therapeutic plasma exchange, steroids, immunoglobulin therapy and pyridostigmine. Despite this, the fetus had arthrogryposis multiplex congenita due to trans-placental transfer of anti-acetylcholine receptor antibodies. The baby was delivered by elective caesarean section at 34weeks of gestation but died in the immediate postpartum period. The mother underwent thymectomy within five weeks of delivery. The implications of myasthenia gravis for both the mother and baby are discussed.
J T Chieza; I Fleming; N Parry; V A Skelton
Publication Detail:
Type:  Journal Article     Date:  2010-11-26
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  20     ISSN:  1532-3374     ISO Abbreviation:  Int J Obstet Anesth     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-82     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Department of Anaesthesia, King's College Hospital NHS Foundation Trust, London, UK.
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