Document Detail


Maternal micronutrients can modify colonic mucosal microbiota maturation in murine offspring.
MedLine Citation:
PMID:  22713270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiologic data suggest that early nutritional exposures may inflict persistent changes in the developing mammalian "super-organism" (i.e., the host and its residing microbiota). Such persistent modifications could predispose young adults to inflammatory bowel diseases (IBD). We recently observed that the dietary supplementation of four micronutrients to dams augmented colitis susceptibility in murine offspring in association with mucosal microbiota composition changes. In this study the effects of the four micronutrients on the microbiota of dams and female mice was examined. Additionally, age dependent microbiota composition shifts during pediatric development were delineated from the previous offspring data sets. Maternal and adult female microbiota did not separate secondary to the nutritional intervention. Significant microbiota composition changes occurred from postnatal day 30 (P30) to P90 at the level of 1 phylum and 15 genera. Most of these changes were absent or opposite in the maternally supplemented offspring. Nutritionally induced alterations in mucosal microbiota maturation may be contributors to colitis susceptibility in mammals.
Authors:
Dorottya Nagy-Szakal; Matthew C Ross; Scot E Dowd; Sabina A V Mir; Tiffany D Schaible; Joseph F Petrosino; Richard Kellermayer
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-20
Journal Detail:
Title:  Gut microbes     Volume:  3     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:    2012 Sep-Oct
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-26     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  426-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacteria / classification*,  drug effects*,  genetics
Biota*
Colon / microbiology*
Feces / microbiology
Female
Metagenome
Mice
Mice, Inbred C57BL
Micronutrients / metabolism*
Grant Support
ID/Acronym/Agency:
5K12 HD041648/HD/NICHD NIH HHS; DK56338/DK/NIDDK NIH HHS; P01 AI057788/AI/NIAID NIH HHS; P30 DK056338/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Micronutrients
Comments/Corrections

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