| Maternal methadone dose during pregnancy and infant clinical outcome. | |
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MedLine Citation:
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PMID: 20102736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In recent decades there has been an increase in the methadone dosages prescribed for opioid dependent women during pregnancy. Using prospective longitudinal data from a cohort of 32 methadone exposed and 42 non-methadone exposed infants, this study examined the relationship between maternal methadone dose during pregnancy and a range of infant clinical outcomes. Of particular interest was the extent to which any observed associations might reflect the direct causal effects of maternal methadone dose and/or the confounding effects of adverse maternal lifestyle factors correlated with methadone use during pregnancy. Findings revealed the presence of clear linear relationships between the mean methadone dose prescribed for mothers during pregnancy and a range of adverse infant clinical outcomes. With increasing maternal methadone dose there was a corresponding increase in infants' risk of being born preterm, being symmetrically smaller, spending longer periods in hospital and the need for treatment for Neonatal Abstinence Syndrome. After due allowance for potentially confounding maternal health and lifestyle factors, maternal methadone dose during pregnancy remained a significant predictor of preterm birth, growth, and the duration of infant hospitalization post delivery. These findings suggest a need to examine more closely the potential impacts of recent trends towards the use of higher methadone dose levels during pregnancy. |
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Authors:
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Trecia A Wouldes; Lianne J Woodward |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-25 |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 32 ISSN: 1872-9738 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 406-13 Citation Subset: IM |
Affiliation:
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Department of Psychological Medicine, University of Auckland, New Zealand. t.wouldes@auckland.ac.nz <t.wouldes@auckland.ac.nz> |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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epidemiology,
etiology* Birth Weight / drug effects Dose-Response Relationship, Drug Female Humans Infant, Newborn Longitudinal Studies Maternal Exposure / adverse effects* Methadone / administration & dosage*, adverse effects* Neonatal Abstinence Syndrome / epidemiology, etiology* Opioid-Related Disorders / rehabilitation Pregnancy Pregnancy Complications / rehabilitation Pregnancy Outcome* / epidemiology Prospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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