Document Detail

Maternal methadone dose during pregnancy and infant clinical outcome.
MedLine Citation:
PMID:  20102736     Owner:  NLM     Status:  MEDLINE    
In recent decades there has been an increase in the methadone dosages prescribed for opioid dependent women during pregnancy. Using prospective longitudinal data from a cohort of 32 methadone exposed and 42 non-methadone exposed infants, this study examined the relationship between maternal methadone dose during pregnancy and a range of infant clinical outcomes. Of particular interest was the extent to which any observed associations might reflect the direct causal effects of maternal methadone dose and/or the confounding effects of adverse maternal lifestyle factors correlated with methadone use during pregnancy. Findings revealed the presence of clear linear relationships between the mean methadone dose prescribed for mothers during pregnancy and a range of adverse infant clinical outcomes. With increasing maternal methadone dose there was a corresponding increase in infants' risk of being born preterm, being symmetrically smaller, spending longer periods in hospital and the need for treatment for Neonatal Abstinence Syndrome. After due allowance for potentially confounding maternal health and lifestyle factors, maternal methadone dose during pregnancy remained a significant predictor of preterm birth, growth, and the duration of infant hospitalization post delivery. These findings suggest a need to examine more closely the potential impacts of recent trends towards the use of higher methadone dose levels during pregnancy.
Trecia A Wouldes; Lianne J Woodward
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-01-25
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  32     ISSN:  1872-9738     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-07-02     Revised Date:  2013-11-29    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  406-13     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  etiology*
Birth Weight / drug effects
Dose-Response Relationship, Drug
Infant, Newborn
Longitudinal Studies
Maternal Exposure / adverse effects*
Methadone / administration & dosage*,  adverse effects*
Neonatal Abstinence Syndrome / epidemiology,  etiology*
Opioid-Related Disorders / rehabilitation
Pregnancy Complications / rehabilitation
Pregnancy Outcome* / epidemiology
Prospective Studies
Risk Factors
Reg. No./Substance:
Comment In:
Neurotoxicol Teratol. 2013 Sep-Oct;39:116-8   [PMID:  23416427 ]
Neurotoxicol Teratol. 2013 Sep-Oct;39:119-21   [PMID:  24099622 ]

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