| Maternal metabolism and obesity: modifiable determinants of pregnancy outcome. | |
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MedLine Citation:
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PMID: 19966268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obesity among pregnant women is highly prevalent worldwide and is associated in a linear manner with markedly increased risk of adverse outcome for mother and infant. Obesity in the mother may also independently confer risk of obesity to her child. The role of maternal metabolism in determining these outcomes and the potential for lifestyle modification are largely unknown. METHODS: Relevant studies were identified by searching PubMed, the metaRegister of clinical trials and Google Scholar without limitations. Sensitive search strategies were combined with relevant medical subject headings and text words. RESULTS: Maternal obesity and gestational weight gain have a significant impact on maternal metabolism and offspring development. Insulin resistance, glucose homeostasis, fat oxidation and amino acid synthesis are all disrupted by maternal obesity and contribute to adverse outcomes. Modification of lifestyle is an effective intervention strategy for improvement of maternal metabolism and the prevention of type 2 diabetes and, potentially, gestational diabetes. CONCLUSIONS: Maternal obesity requires the development of effective interventions to improve pregnancy outcome. Strategies that incorporate a detailed understanding of the maternal metabolic environment and its consequences for the health of the mother and the growth of the child are likely to identify the best approach. |
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Authors:
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Scott M Nelson; Phillippa Matthews; Lucilla Poston |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-12-04 |
Journal Detail:
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Title: Human reproduction update Volume: 16 ISSN: 1460-2369 ISO Abbreviation: Hum. Reprod. Update Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-04-06 Completed Date: 2010-07-01 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9507614 Medline TA: Hum Reprod Update Country: England |
Other Details:
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Languages: eng Pagination: 255-75 Citation Subset: IM |
Affiliation:
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Division of Developmental Medicine, Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, UK. s.nelson@clinmed.gla.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diabetes Mellitus, Type 2
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prevention & control Diabetes, Gestational / prevention & control, therapy Female Humans Life Style Obesity / complications, metabolism*, therapy* Pregnancy Pregnancy Complications / metabolism*, therapy* Pregnancy Outcome* Prenatal Exposure Delayed Effects / prevention & control Risk Factors Weight Gain |
| Grant Support | |
ID/Acronym/Agency:
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//Chief Scientist Office |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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