Document Detail


Maternal metabolic abnormalities in twin-to-twin transfusion syndrome at mid-pregnancy.
MedLine Citation:
PMID:  10918625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report abnormal maternal laboratory parameters in twin-to-twin transfusion syndrome (TTTS) at mid-pregnancy. A retrospective chart review was undertaken of 109 patients with TTTS evaluated for placental laser surgery. Complete blood count (CBC), blood type and Rh factor, urine analysis and serum chemistry panel were obtained preoperatively, with the CBC and serum albumin repeated on the first postoperative day. The mean gestational age was 21.2+/-1.7 weeks. Initial abnormal values included hematocrit (32.1+/-3.0%), hemoglobin (11.0+/-1.03 g/dl), serum magnesium (1.71+/-0.17 mg/dl), total protein (6.08+/-0.55 g/dl) and albumin (3.06+/-0.34 g/dl). Despite minimal blood loss and conservative fluid replacement mean hematocrit, hemoglobin, and albumin were 27.3+/-2.74%, 9.3+/-0.94 g/dl and 2.56+/-0.23 g/dl, respectively on postoperative day one. Weight gain (8.0+/-5.5 lb.) and low urinary output were characteristic peri-operative events. Maternal hypoproteinemia and anemia occur in TTTS at mid-pregnancy. This may contribute independently to amniotic fluid production rates in the fetuses, and explain in part the maternal sensitivity to intravenous fluids in multiple pregnancy.
Authors:
J E De Lia; R S Kuhlmann; M G Emery
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Twin research : the official journal of the International Society for Twin Studies     Volume:  3     ISSN:  1369-0523     ISO Abbreviation:  Twin Res     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-11-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9815819     Medline TA:  Twin Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Illinois, Chicago, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amniotic Fluid / metabolism
Anemia / etiology
Blood Loss, Surgical
Blood Proteins / analysis
Cohort Studies
Female
Fetofetal Transfusion / metabolism*,  surgery
Fluid Therapy
Follow-Up Studies
Gestational Age
Hematocrit
Hemoglobins / analysis
Humans
Hypoproteinemia / etiology
Laser Therapy
Magnesium / blood
Placenta / blood supply,  surgery
Pregnancy
Pregnancy Complications / blood,  metabolism*,  urine
Retrospective Studies
Rh-Hr Blood-Group System
Serum Albumin / analysis
Grant Support
ID/Acronym/Agency:
M01 RR-00058/RR/NCRR NIH HHS; M01 RR-00064/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Hemoglobins; 0/Rh-Hr Blood-Group System; 0/Serum Albumin; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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