Document Detail


Maternal marijuana smoking alters respiratory timing in the fetal lamb.
MedLine Citation:
PMID:  1335578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of single and repeated maternal marijuana smoke exposure on fetal breathing movements (FBMs) was investigated in 13 fetal lambs in the third trimester. These animals were surgically instrumented for long-term intrauterine recording of diaphragmatic electromyogram (EMG). Maternal inhalation of marijuana smoke [1.84% tetrahydrocannabinol (THC)] increased FBMs and resulted in a more continuous and regular breathing pattern. There was a significant increase in the number of breaths/h (p < 0.01) and the incidence of FBMs (p < 0.001) in the second hour. Breathing activity returned to presmoke level by the third hour. Duration of the longest breathing epoch was significantly increased from 16.8 +/- 3.3 min to 31.9 +/- 5.2 min (p < 0.005). Instantaneous breathing rate was much more stable in the second hour after marijuana exposure (p < 0.01). Inhalation of placebo smoke did not result in any significant change in either overall breathing activity or continuity and stability of the breathing rate. The effects of marijuana smoke on fetal breathing were not observed after repeated smoke exposure. These results suggest that tolerance develops rapidly to the respiratory stimulating effect of marijuana smoke in the fetus.
Authors:
H H Szeto; D L Wu; Y Cheng; P Y Cheng; J A Decena
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  43     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-01     Completed Date:  1993-02-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1227-31     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Cornell University Medical College, New York, NY 10021.
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MeSH Terms
Descriptor/Qualifier:
Animals
Electromyography
Female
Fetus / physiopathology*
Marijuana Smoking / physiopathology*
Pregnancy
Respiratory Mechanics / drug effects*
Sheep
Tetrahydrocannabinol / pharmacology
Grant Support
ID/Acronym/Agency:
DA-00100/DA/NIDA NIH HHS; DA-03722/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
1972-08-3/Tetrahydrocannabinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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