Document Detail

Maternal manipulation of brown adipose tissue and liver development in the ovine fetus during late gestation.
MedLine Citation:
PMID:  9227185     Owner:  NLM     Status:  MEDLINE    
We examined the effect of maternal chronic cold exposure, induced by winter-shearing ewes 4 weeks before their predicted lambing date, on brown adipose tissue (BAT) and liver development in lambs. Fetuses were sampled from under-fed (60% of energy requirements for maintenance and pregnancy of an unshorn ewe) shorn or unshorn ewes at 126, 140 and 145 d of gestation. Lambs were sampled from ewes within 2 h of birth. Throughout gestation fetal body, BAT and liver weights were similar in shorn and unshorn groups. The level of GDP binding to mitochondrial uncoupling protein remained low throughout gestation, but increased dramatically after birth. Lambs born to shorn ewes possessed more mitochondrial protein and exhibited a significantly higher total thermogenic activity in BAT. Type I iodothyronine 5' deiodinase (EC activity in BAT peaked at birth, as did hepatic iodothyronine 5' deiodinase activity and was significantly greater in lambs born to under-fed shorn ewes, which exhibited a higher plasma triiodothyronine concentration. Chronic maternal adaptations to prolonged cold exposure appear to enable pregnant ewes to compensate for the negative effects of under-feeding on fetal growth and development.
L Clarke; M J Bryant; M A Lomax; M E Symonds
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  77     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-08-01     Completed Date:  1997-08-01     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  871-83     Citation Subset:  IM    
School of Animal and Microbial Sciences, University of Reading, Whiteknights.
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MeSH Terms
Adaptation, Physiological*
Adipose Tissue, Brown / embryology*,  metabolism
Analysis of Variance
Cold Temperature*
Embryonic and Fetal Development
Epinephrine / metabolism
Gestational Age
Iodide Peroxidase / metabolism
Liver / embryology*
Norepinephrine / metabolism
Nutrition Disorders / metabolism,  veterinary*
Sheep Diseases / metabolism*
Triiodothyronine / blood
Grant Support
//Wellcome Trust
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 6893-02-3/Triiodothyronine; EC Peroxidase

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