| Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts. | |
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MedLine Citation:
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PMID: 21535328 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oral Diseases (2011) Objective: To explore the risk factors of non-syndromic orofacial clefts. Subjects and Methods: A case-control study was conducted in China, 537 infants born with non-syndromic cleft lip with/without cleft palate, 176 infants born with cleft palate (CP), and 221 normal controls were recruited to participate in a questionnaire based study to identify risk factors related to maternal nutrition. Results: Single-factor Chi-square analysis identified 12 factors as significantly related to non-syndromic orofacial clefts (P < 0.05). Multiple logistic regression showed five of these factors were associated with non-syndromic orofacial clefts, male gender and maternal passive smoking during early pregnancy were risk factors for non-syndromic orofacial clefts (OR = 1.86 and 11.42; 95%CI: 2.28-2.69 and 6.87-19.00, respectively), whereas maternal weight gain during pregnancy and folic acid supplementation during early pregnancy were protective (OR = 0.15 and 0.67; 95%CI: 0.034-0.63 and 0.44-1.00, respectively). Conclusions: Our data may provide references for cleft lip and CP prevention programs, and counseling programs in China. |
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Authors:
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Z-L Jia; B Shi; C-H Chen; J-Y Shi; J Wu; X Xu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-11 |
Journal Detail:
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Title: Oral diseases Volume: - ISSN: 1601-0825 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508565 Medline TA: Oral Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 John Wiley & Sons A/S. |
Affiliation:
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State Key Laboratory of Oral Disease Department of Cleft Lip and Palate Surgery, West China College of Stomatology, Sichuan University, Chengdu, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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