Document Detail


Maternal malnutrition does not affect fetal hepatic glycogen synthase ontogeny.
MedLine Citation:
PMID:  8344107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maternal malnutrition late in pregnancy results in the reduced storage of fetal hepatic glycogen in the final days of gestation and an accentuation of normal birth-related hypoglycemia. It was of interest to determine whether or not low glycogen levels resulted when maternal malnutrition disrupted the normal ontogeny of fetal hepatic glycogen synthase, an important glycogenic enzyme. A defect in this enzyme would be expected to seriously affect prenatal and postnatal glycogen synthesis. For this study, livers were removed from fetuses from malnourished (50% of normal dietary intake) mice, as well as from ad libitum-fed mice, and used for the determination of hepatic glycogen, glycogen synthase activity, and glycogen synthase protein levels. In this paper we report that maternal dietary restriction late in pregnancy produces growth-retarded fetuses with severely reduced hepatic glycogen levels, but the normal ontogenic changes in the quantity and activity of hepatic glycogen synthase were not affected. It is especially significant that the accumulation of glycogen synthase occurred despite the minimal level of natural substrate available for the enzyme. These results suggest that the accumulation and activity of hepatic glycogen synthase during late gestation is related to developmental events rather than levels of substrate or glycogen.
Authors:
S D Hsu; R R Cardell; R L Drake
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  38     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-07     Completed Date:  1993-09-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1500-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Anatomy and Cell Biology, University of Cincinnati College of Medicine, Ohio 45267.
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Fetal Growth Retardation / metabolism
Fetus / enzymology*
Gestational Age
Glycogen / analysis*
Glycogen Synthase / metabolism*
Liver / chemistry,  embryology*,  enzymology
Mice
Nutrition Disorders / metabolism*
Pregnancy
Pregnancy Complications / metabolism*
Grant Support
ID/Acronym/Agency:
DK27097/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
9005-79-2/Glycogen; EC 2.4.1.11/Glycogen Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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