Document Detail

Maternal malignant melanoma with placental metastasis: a case report with literature review.
MedLine Citation:
PMID:  2654902     Owner:  NLM     Status:  MEDLINE    
Histologic detection of micrometastatic melanoma in the placenta led to the clinical diagnosis in the mother. Metastases were present in the intervillous space and in villous stroma. The infant has survived and has no evidence of disease at one year of age. The mother died of metastatic disease 6 months post-partum. Literature review shows that only 25% of infants with placental metastatic melanoma succumb to the disease. In a review series of 16 cases, there are some maternal clinical factors which seem to have some bearing on the likelihood of fetal metastasis and death from disease. Features that are associated with an unfavorable fetal/infant prognosis are: maternal age less than 30 years, primiparity, leg primary site, disease onset greater than 3 years prior to pregnancy, node-1 metastatic status prior to pregnancy, M4 status in third trimester, birth at greater than 36 weeks' gestation, male sex. Extent of penetration of metastases into the villi does not have prognostic significance.
J F Anderson; S Kent; G A Machin
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Pediatric pathology / affiliated with the International Paediatric Pathology Association     Volume:  9     ISSN:  0277-0938     ISO Abbreviation:  Pediatr Pathol     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-22     Completed Date:  1989-06-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8303527     Medline TA:  Pediatr Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM    
Department of Family Practice, Victoria General Hospital, British Columbia, Canada.
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MeSH Terms
Chorionic Villi*
Infant, Newborn
Melanoma / pathology,  secondary*
Neoplasms, Unknown Primary / pathology
Placenta Diseases / pathology
Pregnancy Complications, Neoplastic / pathology*
Risk Factors

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