Document Detail

Maternal luteoma of pregnancy presenting with virilization of the female infant.
MedLine Citation:
PMID:  17915067     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Virilization in female newborns typically results from congenital adrenal hyperplasia, requiring immediate diagnosis and treatment. We report a rare cause of virilization, maternal pregnancy luteoma, responsible for virilization of both a newborn and the mother. Luteomas are usually asymptomatic tumour-like ovarian lesions of pregnancy that secrete androgens in only 25% of cases. Many female infants born to masculinized mothers will also be virilized. CASE: A term infant born with ambiguous genitalia was transferred to a referral centre for investigation, diagnosis, and treatment. Assessment identified Prader II-III genitalia, an elevated serum testosterone level, a normal serum 17-hydroxyprogesterone level, and a normal female karyotype (46,XX). The mother had had virilization from the second trimester and was found to have an elevated serum testosterone level. Pelvic ultrasound assessment in the mother showed a complex right ovarian mass. Laparotomy was performed, and the mass was excised. Histopathology examination confirmed a luteoma. CONCLUSION: High maternal serum testosterone levels due to a luteoma can result in virilization in the female newborn. This report emphasizes the need to consider possible underlying maternal pathology in evaluating a virilized female infant.
Rachel F Spitzer; Diane Wherrett; David Chitayat; Terence Colgan; Jason Esli Dodge; Joao Luiz Pippi Salle; Lisa Allen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  29     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-04     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  835-40     Citation Subset:  IM    
Section of Gynecology, Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children, Toronto ON.
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MeSH Terms
Infant, Newborn
Luteoma / blood,  diagnosis*
Ovarian Neoplasms / blood,  diagnosis*
Pregnancy Complications, Neoplastic / diagnosis*
Testosterone / blood*
Virilism / blood*
Reg. No./Substance:

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