Document Detail


Maternal low-protein diet during lactation programmes body composition and glucose homeostasis in the adult rat offspring.
MedLine Citation:
PMID:  17524178     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously we have reported that maternal malnutrition during lactation programmes body weight and thyroid function in the adult offspring. In the present study we evaluated the effect of maternal protein restriction during lactation upon body composition and hormones related to glucose homeostasis in adult rats. During lactation, Wistar lactating rats and their pups were divided into two experimental groups: control (fed a normal diet; 23% protein) and protein-restricted (PR; fed a diet containing 8% protein). At weaning, offspring received a normal diet until they were 180 d old. Body weight (BW) and food intake were monitored. Serum, adrenal glands, visceral fat mass (VFM) and carcasses were collected. PR rats showed lower BW (-13%; P < 0.05), VFM (-33%; P < 0.05), total body fat (-33%; P < 0.05), serum glucose (-7%; P < 0.05), serum insulin (-26%, P < 0.05), homeostasis model assessment index (-20%), but higher total adrenal catecholamine content (+90%; P < 0.05) and serum corticosterone concentration (+51%; P < 0.05). No change was observed in food intake, protein mass or total body water. The lower BW of PR rats is due to a reduction of white fat tissue, probably caused by an increase in lipolysis or impairment of lipogenesis; both effects could be related to higher catecholaminergic status, as well as to hypoinsulinaemia. To conclude, changes in key hormones which control intermediary metabolism are programmed by maternal protein restriction during lactation, resulting in BW alterations in adult rats.
Authors:
A T S Fagundes; E G Moura; M C F Passos; E Oliveira; F P Toste; I T Bonomo; I H Trevenzoli; R M G Garcia; P C Lisboa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-25
Journal Detail:
Title:  The British journal of nutrition     Volume:  98     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-12-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  922-8     Citation Subset:  IM    
Affiliation:
Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87, Rio de Janeiro, RJ, 20551-030, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Animals, Newborn
Blood Glucose / metabolism*
Body Composition*
Catecholamines / blood
Corticosterone / blood
Diet
Diet, Protein-Restricted*
Eating
Female
Homeostasis
Insulin Resistance
Lactation*
Maternal Nutritional Physiological Phenomena
Protein-Energy Malnutrition / blood,  physiopathology*
Rats
Rats, Wistar
Weight Gain
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Catecholamines; 50-22-6/Corticosterone

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