Document Detail


Maternal life event stress and congenital anomalies.
MedLine Citation:
PMID:  10615840     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used data from a population-based case-control study to explore the relation between certain life events during the periconceptional period and several types of congenital anomalies. We ascertained cases from pregnancies ending in 1987-1989 and randomly selected controls from eligible liveborn infants. In telephone interviews, women reported deaths of anyone close to them. They also reported job losses or separations/divorces, for themselves or anyone close to them. Experiencing at least one stressful event during the periconceptional period was associated with a prevalence odds ratio of 1.4-1.5 for the delivery of infants with conotruncal heart defects, neural tube defects, and isolated cleft lip with or without palate. These associations tended to be restricted to women who were not obese and women with less than or equal to a high school education. This study suggests that women who experience stressful life events around the time of conception or early gestation may be at increased risk of delivering infants with certain congenital anomalies.
Authors:
S L Carmichael; G M Shaw
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  11     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-01-19     Completed Date:  2000-01-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Affiliation:
March of Dimes/California Birth Defects Monitoring Program, Emeryville, CA 94608, USA.
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MeSH Terms
Descriptor/Qualifier:
Congenital Abnormalities / diagnosis,  epidemiology,  etiology*
Female
Fetal Death
Heart Defects, Congenital / diagnosis,  epidemiology,  etiology
Humans
Infant
Infant, Newborn
Life Change Events*
Limb Deformities, Congenital / diagnosis,  epidemiology,  etiology
Maternal Welfare
Mouth Abnormalities / diagnosis,  epidemiology,  etiology
Neural Tube Defects / diagnosis,  epidemiology,  etiology
Odds Ratio
Pregnancy
Pregnancy Outcome
Prenatal Exposure Delayed Effects
Prevalence
Questionnaires
Retrospective Studies
Stress, Psychological / complications*
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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