| Maternal life event stress and congenital anomalies. | |
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MedLine Citation:
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PMID: 10615840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used data from a population-based case-control study to explore the relation between certain life events during the periconceptional period and several types of congenital anomalies. We ascertained cases from pregnancies ending in 1987-1989 and randomly selected controls from eligible liveborn infants. In telephone interviews, women reported deaths of anyone close to them. They also reported job losses or separations/divorces, for themselves or anyone close to them. Experiencing at least one stressful event during the periconceptional period was associated with a prevalence odds ratio of 1.4-1.5 for the delivery of infants with conotruncal heart defects, neural tube defects, and isolated cleft lip with or without palate. These associations tended to be restricted to women who were not obese and women with less than or equal to a high school education. This study suggests that women who experience stressful life events around the time of conception or early gestation may be at increased risk of delivering infants with certain congenital anomalies. |
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Authors:
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S L Carmichael; G M Shaw |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epidemiology (Cambridge, Mass.) Volume: 11 ISSN: 1044-3983 ISO Abbreviation: Epidemiology Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-01-19 Completed Date: 2000-01-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9009644 Medline TA: Epidemiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 30-5 Citation Subset: IM |
Affiliation:
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March of Dimes/California Birth Defects Monitoring Program, Emeryville, CA 94608, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Congenital Abnormalities
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diagnosis,
epidemiology,
etiology* Female Fetal Death Heart Defects, Congenital / diagnosis, epidemiology, etiology Humans Infant Infant, Newborn Life Change Events* Limb Deformities, Congenital / diagnosis, epidemiology, etiology Maternal Welfare Mouth Abnormalities / diagnosis, epidemiology, etiology Neural Tube Defects / diagnosis, epidemiology, etiology Odds Ratio Pregnancy Pregnancy Outcome Prenatal Exposure Delayed Effects Prevalence Questionnaires Retrospective Studies Stress, Psychological / complications* Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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