Document Detail


Maternal late-pregnancy serum 25-hydroxyvitamin D in relation to childhood wheeze and atopic outcomes.
MedLine Citation:
PMID:  22707522     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Studies exploring the relationship between prenatal vitamin D exposure and childhood asthma have yielded conflicting results. Higher vitamin D intake during pregnancy has been shown to lower the risk of childhood wheeze, yet a study of maternal late-pregnancy serum 25-hydroxyvitamin D suggested higher serum concentrations may be associated with increased childhood asthma.
OBJECTIVE: To assess the relationship between mothers' serum 25-hydroxyvitamin D status and asthma and wheeze phenotypes in their children at age 6 years. Also to explore the relationship between maternal 25-hydroxyvitamin D status and objective measures of childhood atopy and lung function.
METHODS: Serum 25-hydroxyvitamin D was measured at 34 weeks' gestation in the mothers of 860 children born at term. Wheeze was classified as either transient or persistent/late using questionnaire data collated from 6, 12, 24 and 36 months and 6 years. At 6 years spirometry was performed and atopic status was determined by skin prick testing, exhaled nitric oxide was measured in 451 children and bronchial hyperresponsiveness in 216 children.
RESULTS: There were no significant associations between maternal late-pregnancy 25-hydroxyvitamin D status and either asthma or wheeze at age 6 years. Maternal vitamin D status was not associated with transient or persistent/late wheeze; no significant association was found between persistent/late wheeze when subdivided according to atopic status. No associations were found with skin sensitisation or lung function.
CONCLUSIONS: This study provides no evidence that exposure to higher concentrations of 25-hydroxyvitamin D in maternal serum during late pregnancy increases the risk of childhood asthma, wheeze or atopy.
Authors:
Katharine C Pike; Hazel M Inskip; Sian Robinson; Jane S Lucas; Cyrus Cooper; Nicholas C Harvey; Keith M Godfrey; Graham Roberts;
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-15
Journal Detail:
Title:  Thorax     Volume:  67     ISSN:  1468-3296     ISO Abbreviation:  Thorax     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-26     Completed Date:  2013-01-09     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  England    
Other Details:
Languages:  eng     Pagination:  950-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Asthma / chemically induced*,  epidemiology,  physiopathology
Child
Child, Preschool
Dermatitis, Atopic / chemically induced*,  epidemiology,  physiopathology
Diet
Female
Follow-Up Studies
Free Radical Scavengers / analysis
Great Britain / epidemiology
Health Surveys
Humans
Infant
Nitric Oxide / analysis
Pregnancy
Pregnancy Complications / blood,  chemically induced*,  physiopathology
Pregnancy Trimester, Third*
Questionnaires
Respiratory Sounds / drug effects*,  physiopathology
Risk Factors
Skin Tests
Spirometry
Vitamin D / adverse effects,  analogs & derivatives*,  blood
Grant Support
ID/Acronym/Agency:
17702//Arthritis Research UK; MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1017//Medical Research Council; RG/07/009/23120//British Heart Foundation; SP/02/003/14542//British Heart Foundation; //British Heart Foundation; //Medical Research Council
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 1406-16-2/Vitamin D; 31C4KY9ESH/Nitric Oxide; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

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