| Maternal lamotrigine treatment and elevated neonatal gamma-glutamyl transpeptidase. | |
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MedLine Citation:
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PMID: 16939865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lamotrigine is an antiepileptic drug with a low adverse-effect profile. This report describes an infant born to an epileptic mother treated with lamotrigine, who had a highly elevated gamma-glutamyl transpeptidase level after birth. There was no other clinical or biochemical evidence of liver or bile duct dysfunction. Infant serum level of lamotrigine, which crosses the placenta, was within therapeutic limits. Gamma-glutamyl transpeptidase levels declined slowly during the following months. We suggest that, in the absence of additional markers of tissue damage, the infant's gamma-glutamyl transpeptidase elevation was caused by maternal intake of lamotrigine. Liver function tests should be monitored in infants of lamotrigine treated mothers, as enzyme elevation might still suggest liver damage. |
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Authors:
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Gal Dubnov-Raz; Rivka Shapiro; Paul Merlob |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric neurology Volume: 35 ISSN: 0887-8994 ISO Abbreviation: Pediatr. Neurol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-30 Completed Date: 2006-11-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508183 Medline TA: Pediatr Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 220-2 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Rabin Medical Center, Beilinson Campus, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel. gal-d@bezeqint.ne |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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therapeutic use* Epilepsy / drug therapy* Female Humans Infant, Newborn Jaundice, Neonatal / enzymology* Liver Function Tests Male Pregnancy Pregnancy Complications / drug therapy* Triazines / therapeutic use* gamma-Glutamyltransferase / blood* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Triazines; 84057-84-1/lamotrigine; EC 2.3.2.2/gamma-Glutamyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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