| Maternal "junk-food" feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring. | |
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MedLine Citation:
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PMID: 21427213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Individuals exposed to high-fat, high-sugar diets before birth have an increased risk of obesity in later life. Recent studies have shown that these offspring exhibit increased preference for fat, leading to suggestions that perinatal exposure to high-fat, high-sugar foods results in permanent changes within the central reward system that increase the subsequent drive to overconsume palatable foods. The present study has determined the effect of a maternal "junk-food" diet on the expression of key components of the mesolimbic reward pathway in the offspring of rat dams at 6 wk and 3 mo of age. We show that offspring of junk-food-fed (JF) dams exhibit higher fat intake from weaning until at least 3 mo of age (males: 16 ± 0.6 vs. 11 ± 0.8 g/kg/d; females: 19 ± 1.3 vs. 13 ± 0.4 g/kg/d; P<0.01). mRNA expression of μ-opioid receptor (Mu) was 1.6-fold higher (P<0.01) and dopamine active transporter (DAT) was 2-fold lower (P<0.05) in JF offspring at 6 wk of age. By 3 mo, these differences were reversed, and Mu mRNA expression was 2.8-fold lower (P<0.01) and DAT mRNA expression was 1.9-fold higher (P<0.01) in the JF offspring. These findings suggest that perinatal exposure to high-fat, high-sugar diets results in altered development of the central reward system, resulting in increased fat intake and altered response of the reward system to excessive junk-food intake in postnatal life. |
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Authors:
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Z Y Ong; B S Muhlhausler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-22 |
Journal Detail:
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Title: FASEB journal : official publication of the Federation of American Societies for Experimental Biology Volume: 25 ISSN: 1530-6860 ISO Abbreviation: FASEB J. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-01 Completed Date: 2011-09-28 Revised Date: 2012-09-19 |
Medline Journal Info:
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Nlm Unique ID: 8804484 Medline TA: FASEB J Country: United States |
Other Details:
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Languages: eng Pagination: 2167-79 Citation Subset: IM |
Affiliation:
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Sansom Institute for Health Research, School of Pharmacy and Medical Science, University of South Australia, Adelaide, South Australia, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Nutritional Physiological Phenomena
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physiology* Animals Animals, Newborn Body Weight / drug effects Dietary Fats / administration & dosage Dietary Sucrose / administration & dosage Dopamine Plasma Membrane Transport Proteins / genetics Female Food Preferences / drug effects, physiology* Gene Expression / drug effects Lactation Leptin / blood Limbic System / physiology Male Neural Pathways / drug effects Nucleus Accumbens / metabolism Pregnancy Prenatal Exposure Delayed Effects* Rats Rats, Wistar Receptors, Opioid, mu / genetics Reverse Transcriptase Polymerase Chain Reaction Reward* Ventral Tegmental Area / metabolism Weaning |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Dietary Sucrose; 0/Dopamine Plasma Membrane Transport Proteins; 0/Leptin; 0/Receptors, Opioid, mu |
| Comments/Corrections | |
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