Document Detail


Maternal "junk-food" feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring.
MedLine Citation:
PMID:  21427213     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Individuals exposed to high-fat, high-sugar diets before birth have an increased risk of obesity in later life. Recent studies have shown that these offspring exhibit increased preference for fat, leading to suggestions that perinatal exposure to high-fat, high-sugar foods results in permanent changes within the central reward system that increase the subsequent drive to overconsume palatable foods. The present study has determined the effect of a maternal "junk-food" diet on the expression of key components of the mesolimbic reward pathway in the offspring of rat dams at 6 wk and 3 mo of age. We show that offspring of junk-food-fed (JF) dams exhibit higher fat intake from weaning until at least 3 mo of age (males: 16 ± 0.6 vs. 11 ± 0.8 g/kg/d; females: 19 ± 1.3 vs. 13 ± 0.4 g/kg/d; P<0.01). mRNA expression of μ-opioid receptor (Mu) was 1.6-fold higher (P<0.01) and dopamine active transporter (DAT) was 2-fold lower (P<0.05) in JF offspring at 6 wk of age. By 3 mo, these differences were reversed, and Mu mRNA expression was 2.8-fold lower (P<0.01) and DAT mRNA expression was 1.9-fold higher (P<0.01) in the JF offspring. These findings suggest that perinatal exposure to high-fat, high-sugar diets results in altered development of the central reward system, resulting in increased fat intake and altered response of the reward system to excessive junk-food intake in postnatal life.
Authors:
Z Y Ong; B S Muhlhausler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-22
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  25     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-01     Completed Date:  2011-09-28     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2167-79     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena / physiology*
Animals
Animals, Newborn
Body Weight / drug effects
Dietary Fats / administration & dosage
Dietary Sucrose / administration & dosage
Dopamine Plasma Membrane Transport Proteins / genetics
Female
Food Preferences / drug effects,  physiology*
Gene Expression / drug effects
Lactation
Leptin / blood
Limbic System / physiology
Male
Neural Pathways / drug effects
Nucleus Accumbens / metabolism
Pregnancy
Prenatal Exposure Delayed Effects*
Rats
Rats, Wistar
Receptors, Opioid, mu / genetics
Reverse Transcriptase Polymerase Chain Reaction
Reward*
Ventral Tegmental Area / metabolism
Weaning
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Sucrose; 0/Dopamine Plasma Membrane Transport Proteins; 0/Leptin; 0/Receptors, Opioid, mu
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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