Document Detail


Maternal intravenous ethanol in the prevention of respiratory distress syndrome.
MedLine Citation:
PMID:  331953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The occurrence of respiratory distress syndrome (RDS) was studied in 68 premature neonates whose mothers were treated with at least one six-hour course of intravenous ethyl alcohol within 48 hours before delivery. At the gestational interval of 28 to 32 weeks, significant differences were observed in the incidence of RDS (p = less than 0.05), in severe RDS (p = less than 0.005), and in the mortality rate from RDS ( = less than 0.05), when compared to premature neonates not treated with alcohol and delivered during the same time interval. Several high-risk factors were found unevenly distributed between treated and control groups of patients, and their relevance to RDS was discussed. Premature rupture of membranes of more than 24 hours did not protect infants from RDS in the patients studied. Explanations for possible mechanisms of action are discussed.
Authors:
M I Barrada; N L Viring; L E Edwards; E Y Hakanson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  129     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-10-20     Completed Date:  1977-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Apgar Score
Clinical Trials as Topic
Ethanol / administration & dosage,  therapeutic use*
Female
Gestational Age
Humans
Hyaline Membrane Disease / epidemiology
Infant, Newborn
Infant, Premature
Infusions, Parenteral
Maternal-Fetal Exchange*
Minnesota
Obstetric Labor, Premature / drug therapy*
Pregnancy
Respiratory Distress Syndrome, Newborn / epidemiology,  prevention & control*
Chemical
Reg. No./Substance:
64-17-5/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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