Document Detail

Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn.
MedLine Citation:
PMID:  9212029     Owner:  NLM     Status:  MEDLINE    
To evaluate the hypothesis that the proinflammatory cytokines IL-1, IL-6, and tumor necrosis factor-alpha might be the link between prenatal intrauterine infection (IUI) and neonatal brain damage, the authors review the relevant epidemiologic and cytokine literature. Maternal IUI appears to increase the risk of preterm delivery, which in turn is associated with an increased risk of intraventricular hemorrhage, neonatal white matter damage, and subsequent cerebral palsy. IL-1, IL-6, and TNF-alpha have been found associated with IUI, preterm birth, neonatal infections. and neonatal brain damage. Unifying models not only postulate the presence of cytokines in the three relevant maternal/fetal compartments (uterus, fetal circulation, and fetal brain) and the ability of the cytokines to cross boundaries (placenta and blood-brain barrier) between these compartments, but also postulate how proinflammatory cytokines might lead to IVH and neonatal white matter damage during prenatal maternal infection. Interrupting the proinflammatory cytokine cascade might prevent later disability in those born near the end of the second trimester.
O Dammann; A Leviton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pediatric research     Volume:  42     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-09-09     Completed Date:  1997-09-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Department of Neurology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
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MeSH Terms
Blood-Brain Barrier
Brain Injuries / etiology*,  immunology
Cerebral Hemorrhage / etiology
Cerebral Palsy / etiology
Cytokines / physiology*
Infant, Newborn
Infant, Premature
Inflammation Mediators / physiology
Interleukin-1 / physiology
Interleukin-6 / physiology
Leukomalacia, Periventricular / etiology
Models, Biological
Placenta / physiopathology
Pregnancy Complications, Infectious / immunology*
Tumor Necrosis Factor-alpha / physiology
Uterine Diseases / complications,  immunology
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

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