Document Detail


Maternal intake of methyl-donor nutrients and child cognition at 3 years of age.
MedLine Citation:
PMID:  22686384     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Methyl-donor nutrients are substrates for methylation reactions involved in neurodevelopment processes. The role of maternal intake of these nutrients on cognitive performance of the offspring is poorly understood. We examined the associations of maternal intake of folate, vitamin B12, choline, betaine and methionine during the first and second trimesters of pregnancy, with tests of cognitive performance in the offspring at 3 years of age using data from 1210 participants in Project Viva, a prospective pre-birth cohort study in Massachusetts. We assessed nutrient intake with the use of food frequency questionnaires. Children's cognition at age 3 years was evaluated with the Peabody Picture Vocabulary Test III (PPVT-III) and visual-motor skills with the Wide Range Assessment of Visual Motor Abilities test. In multivariable models adjusting for potential sociobehavioural and nutritional confounders, for each 600 µg/day increment in total folate intake during the first trimester, PPVT-III score at age 3 years was 1.6 points [95% confidence interval (CI) 0.1, 3.1; P = 0.04] higher. There was a weak inverse association between vitamin B12 intake during the second trimester and PPVT-III scores [-0.4 points per 2.6 µg/day; 95% CI -0.8, -0.1; P = 0.01]. We did not find associations between choline, betaine or methionine and cognitive outcomes at this age. Results of this study suggest that higher intake of folate in early pregnancy is associated with higher scores on the PPVT-III, a test of receptive language that predicts overall intelligence, at age 3 years.
Authors:
Eduardo Villamor; Sheryl L Rifas-Shiman; Matthew W Gillman; Emily Oken
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-14
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  26     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-12     Completed Date:  2012-11-06     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-35     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adult
Betaine / metabolism
Child Development / physiology*
Child, Preschool
Choline / metabolism
Cognition / physiology*
Cohort Studies
DNA Methylation / physiology*
Diet
Female
Folic Acid / metabolism
Food*
Humans
Massachusetts
Maternal Age
Maternal Nutritional Physiological Phenomena*
Methionine / metabolism
Multivariate Analysis
Pregnancy
Pregnancy Trimester, First
Pregnancy Trimester, Second
Prenatal Exposure Delayed Effects / chemically induced*,  metabolism
Prospective Studies
Questionnaires
Vitamin B 12 / metabolism
Grant Support
ID/Acronym/Agency:
HD34568/HD/NICHD NIH HHS; HL68041/HL/NHLBI NIH HHS; HL69425/HL/NHLBI NIH HHS; HL77504/HL/NHLBI NIH HHS; K24 HD069408/HD/NICHD NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HD034568-05/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
3SCV180C9W/Betaine; 935E97BOY8/Folic Acid; AE28F7PNPL/Methionine; N91BDP6H0X/Choline; P6YC3EG204/Vitamin B 12
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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