| Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy. | |
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MedLine Citation:
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PMID: 20540659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET). METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET. RESULTS: There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET. CONCLUSIONS: Maternal IGF-2 has a significant positive correlation with PET. |
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Authors:
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Sharon M Cooley; Jennifer C Donnelly; Michael P Geary; Charles H Rodeck; Peter C Hindmarsh |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-29 Revised Date: 2011-01-14 |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 658-61 Citation Subset: IM |
Affiliation:
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Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Female Humans Hypertension, Pregnancy-Induced / blood*, diagnosis Infant, Newborn Infant, Newborn, Diseases / epidemiology Insulin-Like Growth Factor Binding Proteins / blood* Insulin-Like Growth Factor I / analysis* Insulin-Like Growth Factor II / analysis* Intensive Care Units, Neonatal / statistics & numerical data Mothers* Patient Admission / statistics & numerical data Pregnancy Pregnancy Outcome Prognosis |
| Chemical | |
Reg. No./Substance:
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0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II |
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