Document Detail

Maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGF BP-3 and the hypertensive disorders of pregnancy.
MedLine Citation:
PMID:  20540659     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational hypertension and pre-eclampsia (PET).
METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a University teaching hospital in London. Statistical analysis was performed using commercial software (SPSS for Windows, version 6.1, SPSS, Chicago, IL), with P < 0.05 as significant. Maternal IGF 1, IGF 2 and IGF BP-3 were assessed on maternal blood at booking. Blood pressure was checked at each visit in conjunction with urine analysis. The Davey & MacGillivray 1988 classification system was used in making the diagnosis of PET.
RESULTS: There was no significant correlation between maternal IGF-1 or IGFBP-3 levels and gestational hypertension or PET. However, a significant positive correlation does exist between maternal IGF-2 levels and PET.
CONCLUSIONS: Maternal IGF-2 has a significant positive correlation with PET.
Sharon M Cooley; Jennifer C Donnelly; Michael P Geary; Charles H Rodeck; Peter C Hindmarsh
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-29     Revised Date:  2011-01-14    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  658-61     Citation Subset:  IM    
Rotunda Hospital, Parnell Street, Dublin 1, Ireland.
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MeSH Terms
Cohort Studies
Hypertension, Pregnancy-Induced / blood*,  diagnosis
Infant, Newborn
Infant, Newborn, Diseases / epidemiology
Insulin-Like Growth Factor Binding Proteins / blood*
Insulin-Like Growth Factor I / analysis*
Insulin-Like Growth Factor II / analysis*
Intensive Care Units, Neonatal / statistics & numerical data
Patient Admission / statistics & numerical data
Pregnancy Outcome
Reg. No./Substance:
0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II

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