Document Detail

Maternal influences on placental development.
MedLine Citation:
PMID:  10873708     Owner:  NLM     Status:  MEDLINE    
Epidemiological evidence suggests that size at birth may affect health in later life. The growth of the fetus may be adversely affected by a suboptimal maternal environment. Understanding placental development and function will help unravel the mechanisms controlling fetal growth. This article poses the problem: how does the maternal environment (uterine or systemic) influence placental development? Critical human placental functions include remodelling maternal uterine spiral arteries to increase the flow of blood to the maternofetal interface, and transferring oxygen and nutrients into the fetal vasculature, all processes involving trophoblast. Gene ablations that affect pregnancy outcome in mice lead to some interesting hypotheses.
J Aplin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  11     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  115-25     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Academic Unit of Obstetrics and Gynaecology, School of Medicine and School of Biological Sciences, University of Manchester, UK.
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MeSH Terms
Embryo Implantation / genetics,  physiology
Maternal-Fetal Exchange / genetics,  physiology*
Placenta / abnormalities,  growth & development*,  physiology
Pregnancy Outcome
Prenatal Exposure Delayed Effects*
Trophoblasts / cytology,  metabolism,  physiology

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