Document Detail


Maternal inflammatory response to microbial invasion of the amniotic cavity: analyses of multiple proteins in the maternal serum.
MedLine Citation:
PMID:  23057959     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: To evaluate the maternal inflammatory response to microbial invasion of the amniotic cavity (MIAC) in women with preterm labor and preterm prelabor rupture of membranes using selected proteins in the maternal serum. Design: A prospective cohort study. Setting: The evaluation of the maternal inflammatory response in the presence of MIAC in preterm labor and preterm prelabor rupture of membranes. Population: One hundred sixteen women with preterm labor and 73 women with preterm prelabor rupture of membranes between the gestational ages of 22(+0-) 33(+6) weeks. Methods: Twenty-seven maternal serum proteins were assayed by a multiple immunoassay. Main outcome measures: The maternal serum inflammatory response was evaluated according to the presence of MIAC. Data were stratified by gestational age. Results: There were few differences in the maternal serum protein levels when MIAC was present in both preterm labor and preterm prelabor rupture of membranes women. In preterm prelabor rupture of membranes, higher levels of interleukin (IL)-18 (median 654 pg/mL vs. 361 pg/mL, p = 0.003) and lower levels of IL-1β (9.5 pg/mL vs. 19.9 pg/mL, p = 0.008) and monocyte chemotactic protein-1 (MCP-1) (139.1 pg/mL vs. 212.6 pg/mL, p = 0.039) were observed in women with MIAC. IL-6 (20.8 pg/mL vs. 13.9 pg/mL, p = 0.019) was the only biomarker that significantly increased in preterm labor complicated with MIAC. All of the differences between preterm labor and preterm prelabor rupture of membranes were observed at less than 32(+0) weeks of gestation. Conclusion: A weak maternal inflammatory response in the serum was observed in women with MIAC.
Authors:
Teresa Cobo; Panagiotis Tsiartas; Marian Kacerovsky; Rose-Marie Holst; David M Hougaard; Kristin Skogstrand; Ulla-Britt Wennerholm; Henrik Hagberg; Bo Jacobsson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
Maternal Fetal Medicine Department, Hospital Clinic, Institute for Biomedical Investigations August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain Department of Obstetrics and Gynecology, Papageorgiou Hospital, Thessaloniki, Greece Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Obstetrics and Gynecology, University Hospital, Hradec Kralove, Czech Republic Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark Institute of Public Health, Oslo, Norway.
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