Document Detail

Maternal identification from skeletal remains of an infant kept by the alleged mother for 16 years with DNA typing.
MedLine Citation:
PMID:  9608709     Owner:  NLM     Status:  MEDLINE    
This is a case study concerning maternal identification by DNA typing at various loci. An infant skeleton was found in the alleged mother's apartment after it was kept for 16 years. We obtained the skeletal remains as well as saliva stains from the alleged mother. DNA typing was conducted for three loci in the HLA class II region (HLA-DQA1, -DPB1, and DRB1), five loci with the AmpliType PM kit (LDLR, GYPA, HBGG, D7S8, and GC), five STR loci (LPL, vWA, F13B, TH01, and TPOX) and D-loop region in mtDNA for maternal identification. Sex determination was accomplished using fluorescent DNA capillary electrophoresis typing. Approximately 5 ng of human DNA was recovered from 1 g of femur bone retrieved from the infant skeletal remains. The probability of two unrelated Japanese sharing the same genotypes was estimated as 7.2 x 10(-11). The combined probability of exclusion that an individual is not the mother was also calculated at 0.998. We therefore conclude that the skeleton is from a female infant, and that there is no inconsistency in the claim that the infant was a daughter of the alleged mother.
T Yamamoto; R Uchihi; T Kojima; H Nozawa; X L Huang; K Tamaki; Y Katsumata
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of forensic sciences     Volume:  43     ISSN:  0022-1198     ISO Abbreviation:  J. Forensic Sci.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-22     Completed Date:  1998-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375370     Medline TA:  J Forensic Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  701-5     Citation Subset:  IM    
Department of Legal Medicine, Nagoya University School of Medicine, Japan.
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MeSH Terms
DNA Fingerprinting*
DNA, Mitochondrial / analysis*
Dental Enamel Proteins / genetics
Femur / chemistry*
Genetic Markers
Histocompatibility Antigens Class II / genetics*
Histocompatibility Testing
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid
Sex Determination (Analysis)
Time Factors
Reg. No./Substance:
0/Amelogenin; 0/DNA, Mitochondrial; 0/Dental Enamel Proteins; 0/Genetic Markers; 0/Histocompatibility Antigens Class II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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