Document Detail

Maternal hypoxia during pregnancy delays the development of motor reflexes in newborn mice.
MedLine Citation:
PMID:  15509895     Owner:  NLM     Status:  MEDLINE    
Prenatal hypoxic-ischemic brain injury is believed to cause permanent neurological deficits in newborns. We investigated the possibility that maternal hypoxia during pregnancy leads to offspring brain damage and its prevention by i.p. administration of MgSO4. Pregnant mice at gestation day 17 were exposed to hypoxia or air following pretreatment with saline or Mg. Newborn mice to mothers exposed to hypoxia demonstrated faster development of morphogenic parameters such as eyelid opening, hair growth and teeth eruption. In addition, hypoxia delayed the development of motor reflexes. Pretreatment with Mg compensates for hypoxia-induced impairment and in some cases accelerates the development of these functions. In conclusion, maternal hypoxia significantly modifies the developmental process of newborn mice. In our study, pretreatment with Mg showed significant prophylactic action against motor impairments.
Hava Golan; Irena Kashtutsky; Mordechai Hallak; Yoram Sorokin; Mahmoud Huleihel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental neuroscience     Volume:  26     ISSN:  0378-5866     ISO Abbreviation:  Dev. Neurosci.     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-10-28     Completed Date:  2005-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
Copyright Information:
2004 S. Karger AG, Basel.
Department of Development and Zlotowski Center for Neuroscience, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
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MeSH Terms
Animals, Newborn
Behavior, Animal
Body Weight
Gestational Age
Hypoxia, Brain* / drug therapy
Magnesium Sulfate / therapeutic use
Mice, Inbred C57BL
Motor Activity / physiology*
Prenatal Exposure Delayed Effects*
Random Allocation
Reflex / physiology*
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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