| Maternal hormones during early pregnancy: a cross-sectional study. | |
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MedLine Citation:
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PMID: 20084544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), alpha-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II. METHODS: About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975-2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case-control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models. RESULTS: In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed. CONCLUSIONS: Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations. |
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Authors:
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Tianhui Chen; Eva Lundin; Kjell Grankvist; Anne Zeleniuch-Jacquotte; Marianne Wulff; Yelena Afanasyeva; Helena Schock; Robert Johansson; Per Lenner; Goran Hallmans; Goran Wadell; Paolo Toniolo; Annekatrin Lukanova |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-19 |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: 21 ISSN: 1573-7225 ISO Abbreviation: Cancer Causes Control Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-08-09 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: Netherlands |
Other Details:
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Languages: eng Pagination: 719-27 Citation Subset: IM |
Affiliation:
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Division of Cancer Epidemiology, German Cancer Research Center, In Neuenheimer Feld 280, Heidelberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Weight Chorionic Gonadotropin / blood* Cross-Sectional Studies Female Humans Insulin-Like Growth Factor I / metabolism* Insulin-Like Growth Factor II / metabolism* Maternal Age Parity Pregnancy Pregnancy Trimester, First / blood* alpha-Fetoproteins / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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CA114329/CA/NCI NIH HHS; CA120061/CA/NCI NIH HHS; R01 CA114329-04/CA/NCI NIH HHS; R01 CA120061-05/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II |
| Comments/Corrections | |
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