| Maternal histidinaemia: pregnancies and offspring outcomes. | |
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MedLine Citation:
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PMID: 15159650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Untreated pregnancies and their outcomes were studied in 10 women with histidinaemia and their 26 pregnancies. The mean maternal assigned histidine level was 727+/-186 micromol/L (range 484-1,053). Six women had classic histidinaemia (assigned level >700 micromol/L) and the remaining four had mild (atypical) histidinaemia. The pregnancies were uneventful, with only one spontaneous loss and 25 live births. Birth measurements were normal and no congenital anomalies were observed. Growth and development were normal in all offspring. IQ among the 23 offspring tested was 103+/-12 (range 79-122). Four offspring required special education for brief periods and one for several years, but this frequency, as well as that of 12% for attention deficit hyperactive disorder, was not significantly different from expected in the general population. It would appear that maternal histidinaemia, unlike maternal phenylketonuria, can be added to the list of maternal inborn errors of metabolism that are nonteratogenic. |
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Authors:
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H L Levy; J J Yu; S E Waisbren |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of inherited metabolic disease Volume: 27 ISSN: 0141-8955 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 2004 |
Date Detail:
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Created Date: 2004-05-25 Completed Date: 2004-12-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 197-204 Citation Subset: IM |
Affiliation:
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Genetic Services, Children's Hospital Boston, Massachusetts 02115, USA. harvey.levy@tch.harvard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amino Acid Metabolism, Inborn Errors / blood, genetics, physiopathology* Birth Weight Child Child Development Cognition Female Histidine / blood* Humans Infant, Newborn Male Pregnancy Pregnancy Complications / blood, physiopathology* Pregnancy Outcome* Prognosis Prospective Studies Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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N01-HD-2-3149/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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71-00-1/Histidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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