| Maternal high-fat intake predisposes nonalcoholic fatty liver disease in C57BL/6 offspring. | |
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MedLine Citation:
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PMID: 20822767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This work aimed to verify the hypothesis that maternal intake of high-fat diet in critical periods of pregnancy and/or suckling period predisposes nonalcoholic fatty liver disease in adult C57BL/6 mice offspring. STUDY DESIGN: Male pups were divided into 5 groups: (1) SC, from standard chow-fed dams; (2) G, from high-fat chow (HF)-fed dams during the gestation (G) period; (3) L, from HF-fed dams during the lactation (L) period; (4) GL, from HF-fed dams during the gestation and lactation (GL) periods; and (5) GL/HF, from HF-fed dams during GL, maintaining an HF diet from postweaning to adulthood. We analyzed body mass, plasma blood, and liver structure. RESULTS: The G offspring showed insulin resistance and lower glucose transporter-2 expression. Hepatic steatosis was present in the G, L, GL, and mainly in GL/HF offspring. Sterol regulatory element-binding protein-1c expression was higher in G, GL, and GL/HF offspring. CONCLUSION: Programming by HF chow predisposes hepatic adverse remodeling in the liver of adult offspring. |
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Authors:
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Bianca M Gregorio; Vanessa Souza-Mello; Jorge J Carvalho; Carlos A Mandarim-de-Lacerda; Marcia B Aguila |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-06 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 495.e1-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Institute of Biology, Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Biomedical Center, Rio de Janeiro, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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metabolism Alkaline Phosphatase / metabolism Analysis of Variance Animals Blood Glucose Blotting, Western Body Weight Dietary Fats / metabolism* Disease Susceptibility / metabolism Enzyme-Linked Immunosorbent Assay Fatty Liver / etiology*, metabolism Female Glucose Tolerance Test Insulin / blood Insulin Resistance Liver / metabolism* Male Maternal Nutritional Physiological Phenomena / physiology* Mice Pregnancy Prenatal Exposure Delayed Effects / metabolism* Radioimmunoassay Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Fats; 0/Tumor Necrosis Factor-alpha; 11061-68-0/Insulin; EC 2.6.1.2/Alanine Transaminase; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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