Document Detail

Maternal hemodynamics at 11-13 weeks' gestation and the risk of preeclampsia.
MedLine Citation:
PMID:  22565361     Owner:  NLM     Status:  Publisher    
Objective: Women who develop preeclampsia are at increased risk of cardiovascular disease and stroke in the subsequent decades. Individuals with cardiovascular disorders have increased central aortic systolic blood pressure and arterial stiffness, as assessed by pulse wave velocity and augmentation index. The aim of this study was to examine the potential value of assessment of aortic systolic blood pressure, pulse wave velocity and augmentation index at 11-13 weeks' gestation in identifying women who subsequently develop preeclampsia. Methods: This was a screening study for preeclampsia in singleton pregnancies at 11(+0) -13(+6) weeks' gestation. Maternal history and characteristics were recorded and pulse wave velocity, augmentation index and aortic systolic blood pressure measured. We compared these parameters in those that developed preeclampsia (n=181) with unaffected controls (n=6,766) and examined their performance in screening for preeclampsia. Results: In the preeclampsia group, compared to unaffected controls, there was an increase in augmentation index-75 (1.13 vs 1.00 MoM, p<0.0001), pulse wave velocity (1.06 vs 1.00 MoM, p<0.0001) and aortic systolic blood pressure (1.09 vs. 1.00 MoM, p<0.0001). In screening for preeclampsia by a combination of maternal variables and log(10) augmentation index-75 MoM, log(10) pulse wave velocity MoM and log(10) aortic systolic blood pressure, the estimated detection rate was 56.9% at a false-positive rate of 10%. Conclusion: Compared with women who remain normotensive, women who develop preeclampsia have higher aortic systolic blood pressure and arterial stiffness that is apparent from the first trimester of pregnancy. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Asma Khalil; Ranjit Akolekar; Argyro Syngelaki; Mohamed Elkhouli; Kypros H Nicolaides
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-7
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Department of Fetal Medicine, Institute for Women's Health, University College London Hospitals, London, UK.
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