Document Detail

Maternal haemolysis, elevated liver enzymes and low platelets syndrome: perinatal and neurodevelopmental neonatal outcomes for infants weighing less than 1250 g.
MedLine Citation:
PMID:  15009576     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study mortality and short-term morbidity of infants born to women with HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome and to compare the long-term neurodevelopmental morbidity of a subgroup with birth weight (BWT) less than 1250 g (study group) with weight matched controls. METHODS: Retrospective chart review and prospective neurodevelopmental follow-up through a Perinatal Follow-up clinic. Analysis of perinatal and neonatal data for women diagnosed with HELLP from 1993 to 1996. Neurodevelopmental outcome for the study group was compared to a group of weight matched controls. RESULTS: A total of 109 infants (mean gestational age 32.6 weeks, mean BWT 1766 g) were born to 104 women with HELLP syndrome. There was a significant decrease in mortality (P = 0.002) and morbidity (P < 0.05) with increasing gestational age and birthweight. No significant differences in neonatal mortality and morbidity were present between the infants weighing less than 1250 g study and weight matched control group. However, at 3 years, the study group had fewer children with cerebral palsy (P = 0.024) and mental disability (P trend = 0.07). Mean cognitive index was 99 versus 91 in the controls (P = 0.101). CONCLUSION: Improved health outcomes occur with increased gestational age. Infants with BWT less than 1250 g born to women with HELLP syndrome were not at risk of increased neurodevelopmental disability compared to controls.
N Singhal; H J Amin; J K Pollard; S C Tough; D W Johnston; D J Clark; R Sauve
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  40     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-10     Completed Date:  2004-07-01     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Division of Neonatology, Department of Paediatrics, University of Calgary, Calgary Health Region, Calgary, Alberta, Canada.
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MeSH Terms
Case-Control Studies
Child, Preschool
Follow-Up Studies
HELLP Syndrome / complications*
Infant, Newborn
Infant, Very Low Birth Weight / growth & development*
Nervous System Diseases / embryology,  etiology
Pregnancy Complications*
Pregnancy Outcome
Prospective Studies
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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