| Maternal haemolysis, elevated liver enzymes and low platelets syndrome: perinatal and neurodevelopmental neonatal outcomes for infants weighing less than 1250 g. | |
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MedLine Citation:
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PMID: 15009576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study mortality and short-term morbidity of infants born to women with HELLP (haemolysis, elevated liver enzymes, and low platelets) syndrome and to compare the long-term neurodevelopmental morbidity of a subgroup with birth weight (BWT) less than 1250 g (study group) with weight matched controls. METHODS: Retrospective chart review and prospective neurodevelopmental follow-up through a Perinatal Follow-up clinic. Analysis of perinatal and neonatal data for women diagnosed with HELLP from 1993 to 1996. Neurodevelopmental outcome for the study group was compared to a group of weight matched controls. RESULTS: A total of 109 infants (mean gestational age 32.6 weeks, mean BWT 1766 g) were born to 104 women with HELLP syndrome. There was a significant decrease in mortality (P = 0.002) and morbidity (P < 0.05) with increasing gestational age and birthweight. No significant differences in neonatal mortality and morbidity were present between the infants weighing less than 1250 g study and weight matched control group. However, at 3 years, the study group had fewer children with cerebral palsy (P = 0.024) and mental disability (P trend = 0.07). Mean cognitive index was 99 versus 91 in the controls (P = 0.101). CONCLUSION: Improved health outcomes occur with increased gestational age. Infants with BWT less than 1250 g born to women with HELLP syndrome were not at risk of increased neurodevelopmental disability compared to controls. |
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Authors:
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N Singhal; H J Amin; J K Pollard; S C Tough; D W Johnston; D J Clark; R Sauve |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of paediatrics and child health Volume: 40 ISSN: 1034-4810 ISO Abbreviation: J Paediatr Child Health Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-10 Completed Date: 2004-07-01 Revised Date: 2007-09-24 |
Medline Journal Info:
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Nlm Unique ID: 9005421 Medline TA: J Paediatr Child Health Country: Australia |
Other Details:
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Languages: eng Pagination: 121-6 Citation Subset: IM |
Affiliation:
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Division of Neonatology, Department of Paediatrics, University of Calgary, Calgary Health Region, Calgary, Alberta, Canada. nalini.singhal@calgaryhealthregion.ca |
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Child, Preschool Female Follow-Up Studies HELLP Syndrome / complications* Humans Infant Infant, Newborn Infant, Very Low Birth Weight / growth & development* Male Nervous System Diseases / embryology, etiology Pregnancy Pregnancy Complications* Pregnancy Outcome Prospective Studies Retrospective Studies |
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