| Maternal growth factor regulation of human placental development and fetal growth. | |
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MedLine Citation:
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PMID: 20817666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal development and function of the placenta is critical to achieving a successful pregnancy, as normal fetal growth depends directly on the transfer of nutrients from mother to fetus via this organ. Recently, it has become apparent from both animal and human studies that growth factors within the maternal circulation, for example the IGFs, are important regulators of placental development and function. Although these factors act via distinct receptors to exert their effects, the downstream molecules activated upon ligand/receptor interaction are common to many growth factors. The expression of numerous signaling molecules is altered in the placentas from pregnancies affected by the fetal growth complications, fetal growth restriction, and macrosomia. Thus, targeting these molecules may lead to more effective treatments for complications of pregnancy associated with altered placental development. Here, we review the maternal growth factors required for placental development and discuss their mechanism of action. |
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Authors:
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Karen Forbes; Melissa Westwood |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-09-03 |
Journal Detail:
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Title: The Journal of endocrinology Volume: 207 ISSN: 1479-6805 ISO Abbreviation: J. Endocrinol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2010-10-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375363 Medline TA: J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 1-16 Citation Subset: IM |
Affiliation:
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School of Biomedicine, Maternal and Fetal Health Research Centre, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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1-Phosphatidylinositol 3-Kinase
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physiology Animals Epidermal Growth Factor / physiology Female Fetal Development / physiology* Fibroblast Growth Factors / physiology Growth Substances / deficiency, genetics, physiology* Humans MAP Kinase Signaling System Mice Mice, Knockout Models, Biological Placentation / physiology* Platelet-Derived Growth Factor / physiology Pregnancy Protein Tyrosine Phosphatases / physiology Proto-Oncogene Proteins c-akt / physiology Signal Transduction Somatomedins / physiology Transforming Growth Factor beta / physiology |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 0/Platelet-Derived Growth Factor; 0/Somatomedins; 0/Transforming Growth Factor beta; 62031-54-3/Fibroblast Growth Factors; 62229-50-9/Epidermal Growth Factor; EC 2.7.1.137/1-Phosphatidylinositol 3-Kinase; EC 2.7.11.1/Proto-Oncogene Proteins c-akt; EC 3.1.3.48/Protein Tyrosine Phosphatases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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