Document Detail


MATERNAL GASTRIC ADENOCARCINOMA WITH PLACENTAL METASTASES: WHAT IS THE FETAL RISK?
MedLine Citation:
PMID:  22339159     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The incidence of maternal cancer during pregnancy is low and metastatic disease involving the placenta is rare. We present a case of rapidly progressive and fatal gastric carcinoma presenting during pregnancy, with spread to the maternal blood space within the placenta but no chorionic villous invasion, and no evidence of fetal transmission at the time of delivery or on 12 month follow-up. To the best of our knowledge, there have been only four previous single case reports of gastric carcinoma metastatic to the placenta. This case highlights the need for clinical vigilance against dismissing gastrointestinal symptoms as pregnancy-related and for pathologists to carefully examine the placenta in the setting of maternal malignancy. Where placental metastases are present but there is no villous invasion, the risk of fetal metastasis may be extremely low, even in the setting of aggressive, terminal malignancy in the mother.
Authors:
Keith Miller; Agnes Zawislak; Caroline Gannon; David Millar; Maurice Loughrey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-17
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Royal Victoria Hospital, Histopathology.
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