Document Detail


Maternal fish oil supplementation in pregnancy reduces interleukin-13 levels in cord blood of infants at high risk of atopy.
MedLine Citation:
PMID:  12680858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVES: The epidemiological association between higher dietary n-3 polyunsaturated fatty acids (PUFA) and lower prevalence of asthma, has led to interest in the role of early dietary modification in allergic disease prevention. In this study we examined the effects of maternal n-3 (PUFA)-rich fish oil supplementation on cord blood (CB) IgE and cytokine levels in neonates at risk of developing allergic disease. METHODS: In a randomized double-blind, placebo-controlled trial, 83 atopic pregnant women received either fish oil capsules (n = 40) containing 3.7 g n-3 PUFA/day or placebo capsules (n = 43) from 20 weeks gestation until delivery. CB cytokine levels (IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, TNF-alpha and IFN-gamma) and total IgE levels were measured and compared between the two groups. Fatty acid composition of red cell membranes was analysed by gas chromatography and the relationships among PUFA, cytokine and IgE levels were examined. RESULTS: Maternal fish oil supplementation resulted in a significant increase in n-3 PUFA levels (P < 0.001) in neonatal erythrocyte membranes. Neonates whose mothers had fish oil supplementation had significantly lower plasma IL-13 (P < 0.05) compared to the control group. There was also a significant inverse relationship between levels of n-3 PUFA in neonatal cell membranes and plasma IL-13. There was no difference in levels of IgE and the other cytokines measured. CONCLUSIONS: This study provides preliminary evidence that increasing neonatal n-3 PUFA levels with maternal dietary supplementation can achieve subtle modification of neonatal cytokine levels. Further assessment of immune function and clinical follow-up of these infants will help determine if there are any significant effects on postnatal immune development and expression of allergic disease.
Authors:
J A Dunstan; T A Mori; A Barden; L J Beilin; A L Taylor; P G Holt; S L Prescott
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology     Volume:  33     ISSN:  0954-7894     ISO Abbreviation:  Clin. Exp. Allergy     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-04-08     Completed Date:  2003-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8906443     Medline TA:  Clin Exp Allergy     Country:  England    
Other Details:
Languages:  eng     Pagination:  442-8     Citation Subset:  IM    
Affiliation:
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia.
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MeSH Terms
Descriptor/Qualifier:
Double-Blind Method
Erythrocyte Membrane / metabolism
Fatty Acids, Omega-3 / blood
Female
Fetal Blood / immunology*
Fish Oils / administration & dosage*
Humans
Hypersensitivity / immunology,  prevention & control*
Immunoglobulin E / blood
Interleukin-12 / blood
Interleukin-13 / blood*
Interleukin-4 / blood
Interleukin-5 / blood
Logistic Models
Longitudinal Studies
Pregnancy / metabolism*
Risk
Tumor Necrosis Factor-alpha / analysis
Chemical
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Interleukin-13; 0/Interleukin-5; 0/Tumor Necrosis Factor-alpha; 187348-17-0/Interleukin-12; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E
Comments/Corrections
Comment In:
Clin Exp Allergy. 2003 Apr;33(4):412-5   [PMID:  12680853 ]

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