Document Detail

Maternal fever and neonatal depression: preliminary observations.
MedLine Citation:
PMID:  10349526     Owner:  NLM     Status:  MEDLINE    
The objectives of this study were to determine in term infants: (1) the importance of maternal fever (maternal temperature > 38 degrees C) as a risk factor for neonatal depression and (2) the clinical course of infants admitted to the Neonatal Intensive Care Unit (NICU) born to mothers with fever. For 2 years, 59 (0.24%) of 25,000 term infants had a 5-minute Apgar score < or = 5 and 22 (0.08%) infants were administered chest compressions with or without epinephrine as part of cardiopulmonary resuscitation (CPR) in the delivery room. The perinatal event most commonly associated with a 5-minute Apgar score < or = 5 was maternal fever in 19 infants (32%), with meconium + fetal heart rate (FTHR) abnormalities in 15 (25%), and FTHR abnormalities only in 13 (22%), additional associations (n = 13). By stepwise linear regression analysis, a 5-minute Apgar < or = 5 was related only to the initial infant temperature (p = 0.009, r = 0.33). Maternal fever noted in six infants (27%) was also commonly associated with CPR, as was the presence of meconium + FTHR abnormalities in seven (32%), and FTHR abnormalities only in four (18%). One hundred thirteen (7.5%) of the approximately 1,500 term infants born to mothers with maternal fever were admitted to the NICU. In addition to fever, the labor was complicated by meconium (in 16 infants), meconium + FTHR abnormalities (in 19 infants), and FTHR abnormalities only (in 11 infants). Resuscitative interventions in the delivery room included oxygen only in 43 infants, bag and mask ventilation in 38, continuous positive airway pressure in 10, intubation in 16, and CPR in six infants. Forty-nine infants (43%) had an initial temperature > 38 degrees C including 13 (11%) with an initial temperature > 39 degrees C. Twelve (10%) infants remained intubated on admission and five required ventilator support > 24 hours. One blood culture was positive although all mothers were pretreated with antibiotics. One infant developed hypoxic ischemic encephalopathy including seizures. Maternal fever is the perinatal event most frequently associated with a 5-minute Apgar score < or = 5 and a common association with the need for CPR. Clinicians attending the delivery of a mother with fever should anticipate the potential for neonatal depression; such awareness should facilitate appropriate preparation before delivery and potentially reduce the need for more intensive resuscitation.
J M Perlman
Related Documents :
16275656 - Occupational fitness standards for beach lifeguards. phase 1: the physiological demands...
8108626 - Hoists for locomotor disability--properties of the person-carrying section and biomecha...
25113916 - Infants' ability to respond to depth from the retinal size of human faces: comparing mo...
5644046 - Adaptation and negative aftereffect to lateral optical displacement in newly hatched ch...
12788986 - Development of the intestinal bacterial composition in hospitalized preterm infants in ...
21143586 - Breastfeeding and reported morbidity during infancy: findings from the southampton wome...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pediatrics     Volume:  38     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-14     Completed Date:  1999-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-91     Citation Subset:  AIM; IM    
Department of Pediatrics, UT Southwestern Medical School, Dallas 75235-9063, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Apgar Score
Cardiopulmonary Resuscitation
Heart Rate
Infant, Newborn
Pregnancy Complications / physiopathology*
Respiratory Insufficiency / etiology*,  therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Delayed pubertal growth spurt and normal adult height attainment in boys receiving long-term alterna...
Next Document:  Correlation of serum cholylglycine level with hepatic dysfunction in children with sickle cell anemi...