| Maternal fever during early pregnancy and the risk of oral clefts. | |
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MedLine Citation:
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PMID: 20099315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increased risk of birth defects after hyperthermic exposures has been confirmed in animal studies, but population studies have yielded inconsistent results. Oral clefts are a common birth defect and have been associated with these exposures in some of these studies. In this study, data from the National Birth Defects Prevention Study was used to evaluate the association of maternal report of febrile illness in early pregnancy and the risk of oral clefts. All oral cleft cases born between 1997 and 2004 were compared with nonmalformed controls born in the same geographical region during the same time period. Mothers reporting febrile illness during pregnancy were stratified by fever grade and antipyretic use. Logistic regression models were used to generate crude and adjusted odds ratios for exposure to fever and association with each oral cleft phenotype. The dataset included 5821 controls, 1567 cases of cleft lip with or without cleft palate (CL+/-P) and 835 cases of cleft palate only. A modestly increased risk was observed for isolated CL+/-P (odds ratio, 1.28; 95% confidence interval, 1.01-1.63). Stratification by fever grade (body temperature <101.5 degrees or > or =101.5 degrees F) did not yield significant differences in risk. Risk estimates were higher among women who reported a fever, but did not take antipyretics to control their fever, particularly for nonisolated compared with isolated oral clefts. This finding suggests that adequate control of fever may diminish the deleterious effects of fever in cases of oral cleft. |
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Authors:
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S Shahrukh Hashmi; M Shayne Gallaway; D Kim Waller; Peter H Langlois; Jacqueline T Hecht; |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 88 ISSN: 1542-0760 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-15 Completed Date: 2010-06-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 186-94 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Wiley-Liss, Inc. |
Affiliation:
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The University of Texas Medical School at Houston, Houston, Texas 77030, USA. syed.s.hashmi.1@uth.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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embryology,
epidemiology,
etiology Adolescent Adult Analgesics, Non-Narcotic / therapeutic use Cleft Lip / embryology, epidemiology, etiology* Cleft Palate / embryology, epidemiology, etiology* Female Fever / drug therapy, epidemiology, physiopathology* Humans Odds Ratio Parity Pregnancy Pregnancy Complications, Infectious / epidemiology, physiopathology* Pregnancy Outcome United States / epidemiology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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U50/CCU613232//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Non-Narcotic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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