Document Detail

Maternal fever during early pregnancy and the risk of oral clefts.
MedLine Citation:
PMID:  20099315     Owner:  NLM     Status:  MEDLINE    
An increased risk of birth defects after hyperthermic exposures has been confirmed in animal studies, but population studies have yielded inconsistent results. Oral clefts are a common birth defect and have been associated with these exposures in some of these studies. In this study, data from the National Birth Defects Prevention Study was used to evaluate the association of maternal report of febrile illness in early pregnancy and the risk of oral clefts. All oral cleft cases born between 1997 and 2004 were compared with nonmalformed controls born in the same geographical region during the same time period. Mothers reporting febrile illness during pregnancy were stratified by fever grade and antipyretic use. Logistic regression models were used to generate crude and adjusted odds ratios for exposure to fever and association with each oral cleft phenotype. The dataset included 5821 controls, 1567 cases of cleft lip with or without cleft palate (CL+/-P) and 835 cases of cleft palate only. A modestly increased risk was observed for isolated CL+/-P (odds ratio, 1.28; 95% confidence interval, 1.01-1.63). Stratification by fever grade (body temperature <101.5 degrees or > or =101.5 degrees F) did not yield significant differences in risk. Risk estimates were higher among women who reported a fever, but did not take antipyretics to control their fever, particularly for nonisolated compared with isolated oral clefts. This finding suggests that adequate control of fever may diminish the deleterious effects of fever in cases of oral cleft.
S Shahrukh Hashmi; M Shayne Gallaway; D Kim Waller; Peter H Langlois; Jacqueline T Hecht;
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  88     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-94     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Wiley-Liss, Inc.
The University of Texas Medical School at Houston, Houston, Texas 77030, USA.
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MeSH Terms
Abnormalities, Multiple / embryology,  epidemiology,  etiology
Analgesics, Non-Narcotic / therapeutic use
Cleft Lip / embryology,  epidemiology,  etiology*
Cleft Palate / embryology,  epidemiology,  etiology*
Fever / drug therapy,  epidemiology,  physiopathology*
Odds Ratio
Pregnancy Complications, Infectious / epidemiology,  physiopathology*
Pregnancy Outcome
United States / epidemiology
Young Adult
Grant Support
U50/CCU613232//PHS HHS
Reg. No./Substance:
0/Analgesics, Non-Narcotic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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