| Maternal and fetal tyrosinemia type I. | |
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MedLine Citation:
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PMID: 23250512 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A 22 year-old woman with tyrosinemia type I (HT1) married her first cousin who is heterozygous for the same FAH mutation for which the patient is homozygous. During her pregnancy she was treated with diet (prescribed tyrosine intake 300 mg/day), and nitisinone (60 mg/day). Median plasma tyrosine levels were 560 μmol/L (range: 375-838, n = 21) and nitisinone 51 μmol/L (range: 41-57, n = 3) during pregnancy. She gave birth to a clinically healthy girl affected with tyrosinemia type 1. Birth was normal (birth weight 2615 g) and the baby had normal liver function, normal plasma alpha-fetoprotein concentrations, low urinary excretion of phenolic acids and no detectable succinylacetone. At birth, the baby had hypertyrosinemia (860 μmol/L in blood cord) and nitisinone levels of 14 μmol/L. Following molecular confirmation of the diagnosis of HT1 specific treatment began on day 15 by which time she had detectable urinary succinylacetone. |
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Authors:
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N Garcia Segarra; S Roche; A Imbard; J F Benoist; M O Grenèche; A Davit-Spraul; H Ogier de Baulny |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-19 |
Journal Detail:
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Title: Journal of inherited metabolic disease Volume: - ISSN: 1573-2665 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Reference Center for Inherited Metabolic Diseases, Hôpital Robert Debré, APHP, 48 Boulevard Sérurier, 75019, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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